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Table 2 Top 5 Gene Ontology (Molecular Function) terms for liver enhancer sets from GREAT and JEME target-mapped WebGestalt enrichments
| Enhancer Set | GO MF Terms (GREAT) | GO MF Terms (JEME+WebGestalt) |
|---|---|---|
| H3K27acPlusH3K4me1 | cytoskeletal adaptor activity | small molecule binding |
| 14–3-3 protein binding | anion binding | |
| leukotriene-C4 synthase activity | nucleoside phosphate binding | |
| nucleobase-containing compound transmembrane transporter activity | nucleotide binding | |
| FAD binding | transferase activity | |
| H3K27acMinusH3K4me3 | 14–3-3 protein binding | oxidoreductase activity |
| cytoskeletal adaptor activity | anion binding | |
| thyroid hormone receptor binding | small molecule binding | |
| ARF guanyl-nucleotide exchange factor activity | nucleoside phosphate binding | |
| high-density lipoprotein particle binding | nucleotide binding | |
| DNasePlusHistone | cytoskeletal adaptor activity | small molecule binding |
| glucocorticoid receptor binding | anion binding | |
| nucleobase-containing compound transmembrane transporter activity | transferase activity | |
| high-density lipoprotein particle binding | nucleotide binding | |
| 14–3-3- protein binding | nucleoside phosphate binding | |
| ChromHMM | high-density lipoprotein particle binding | nucleotide binding |
| nucleobase-containing compound transmembrane transporter activity | nucleoside binding | |
| cytoskeletal adaptor activity | purine nucleoside binding | |
| 14–3-3 protein binding | DNA binding | |
| retinoid X receptor binding | RNA binding | |
| EncodeEnhancerlike | cytoskeletal adaptor activity | nucleotide binding |
| 14–3-3 protein binding | transferase activity | |
| nucleobase-containing compound transmembrane transporter activity | small molecule binding | |
| apolipoprotein A-I binding | anion binding | |
| high-density lipoprotein particle binding | carbohydrate derivative binding | |
| FANTOM | glucocorticoid receptor binding | structural constituent of ribosome |
| protein kinase binding | receptor binding | |
| kinase binding | cell adhesion molecule binding | |
| methylglutaconyl-CoA hydratase activity | molecular function regulator | |
| vitamin D response element binding | transcription regulatory region DNA binding | |
| Villar15 | protease binding | anion binding |
| phosphatidylinositol 3-kinase binding | small molecule binding | |
| 14–3-3 protein binding | oxidoreductase activity | |
| cytoskeletal adaptor activity | cofactor binding | |
| glucocorticoid receptor binding | oxidoreductase activity, acting on CH-OH group of donors |
