Table 2 Top 5 Gene Ontology (Molecular Function) terms for liver enhancer sets from GREAT and JEME target-mapped WebGestalt enrichments

H3K27acPlusH3K4me1

cytoskeletal adaptor activity

small molecule binding

14–3-3 protein binding

anion binding

leukotriene-C4 synthase activity

nucleoside phosphate binding

nucleobase-containing compound transmembrane transporter activity

nucleotide binding

FAD binding

transferase activity

H3K27acMinusH3K4me3

14–3-3 protein binding

oxidoreductase activity

cytoskeletal adaptor activity

anion binding

thyroid hormone receptor binding

small molecule binding

ARF guanyl-nucleotide exchange factor activity

nucleoside phosphate binding

high-density lipoprotein particle binding

nucleotide binding

DNasePlusHistone

cytoskeletal adaptor activity

small molecule binding

glucocorticoid receptor binding

anion binding

nucleobase-containing compound transmembrane transporter activity

transferase activity

high-density lipoprotein particle binding

nucleotide binding

14–3-3- protein binding

nucleoside phosphate binding

ChromHMM

high-density lipoprotein particle binding

nucleotide binding

nucleobase-containing compound transmembrane transporter activity

nucleoside binding

cytoskeletal adaptor activity

purine nucleoside binding

14–3-3 protein binding

DNA binding

retinoid X receptor binding

RNA binding

EncodeEnhancerlike

cytoskeletal adaptor activity

nucleotide binding

14–3-3 protein binding

transferase activity

nucleobase-containing compound transmembrane transporter activity

small molecule binding

apolipoprotein A-I binding

anion binding

high-density lipoprotein particle binding

carbohydrate derivative binding

FANTOM

glucocorticoid receptor binding

structural constituent of ribosome

protein kinase binding

receptor binding

kinase binding

cell adhesion molecule binding

methylglutaconyl-CoA hydratase activity

molecular function regulator

vitamin D response element binding

transcription regulatory region DNA binding

Villar15

protease binding

anion binding

phosphatidylinositol 3-kinase binding

small molecule binding

14–3-3 protein binding

oxidoreductase activity

cytoskeletal adaptor activity

cofactor binding

glucocorticoid receptor binding

oxidoreductase activity, acting on CH-OH group of donors