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Table 2 Top 5 Gene Ontology (Molecular Function) terms for liver enhancer sets from GREAT and JEME target-mapped WebGestalt enrichments

From: Genome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function

Enhancer Set GO MF Terms (GREAT) GO MF Terms (JEME+WebGestalt)
H3K27acPlusH3K4me1 cytoskeletal adaptor activity small molecule binding
14–3-3 protein binding anion binding
leukotriene-C4 synthase activity nucleoside phosphate binding
nucleobase-containing compound transmembrane transporter activity nucleotide binding
FAD binding transferase activity
H3K27acMinusH3K4me3 14–3-3 protein binding oxidoreductase activity
cytoskeletal adaptor activity anion binding
thyroid hormone receptor binding small molecule binding
ARF guanyl-nucleotide exchange factor activity nucleoside phosphate binding
high-density lipoprotein particle binding nucleotide binding
DNasePlusHistone cytoskeletal adaptor activity small molecule binding
glucocorticoid receptor binding anion binding
nucleobase-containing compound transmembrane transporter activity transferase activity
high-density lipoprotein particle binding nucleotide binding
14–3-3- protein binding nucleoside phosphate binding
ChromHMM high-density lipoprotein particle binding nucleotide binding
nucleobase-containing compound transmembrane transporter activity nucleoside binding
cytoskeletal adaptor activity purine nucleoside binding
14–3-3 protein binding DNA binding
retinoid X receptor binding RNA binding
EncodeEnhancerlike cytoskeletal adaptor activity nucleotide binding
14–3-3 protein binding transferase activity
nucleobase-containing compound transmembrane transporter activity small molecule binding
apolipoprotein A-I binding anion binding
high-density lipoprotein particle binding carbohydrate derivative binding
FANTOM glucocorticoid receptor binding structural constituent of ribosome
protein kinase binding receptor binding
kinase binding cell adhesion molecule binding
methylglutaconyl-CoA hydratase activity molecular function regulator
vitamin D response element binding transcription regulatory region DNA binding
Villar15 protease binding anion binding
phosphatidylinositol 3-kinase binding small molecule binding
14–3-3 protein binding oxidoreductase activity
cytoskeletal adaptor activity cofactor binding
glucocorticoid receptor binding oxidoreductase activity, acting on CH-OH group of donors
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BMC Genomics

ISSN: 1471-2164

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