Table 4 Resistance associated variants present as heterozygous alleles (HAs)
Patient ID | Phenotypic resistance | Mutation | Frequency (MGIT/sputum) | Description |
|---|---|---|---|---|
F1002 | Rifampicin | rpoB S450 L | 100%/100% | High confidence resistance mutation |
F1002 | Rifampicin | rpoC G332R [41] | 82.6%/21.7% | Putative compensatory mutations |
F1002 | Rifampicin | rpoC L516P [41] | 12.7%/7.7% | |
F1002 | Rifampicin | rpoC P1040S [42] | 21.7%/12.3% | |
F1066 | Isoniazid (high) | katG N218 fs | 0.0%/6.9% | Possible resistance mutations, not previously described |
F1066 | Clofazimine – not tested | Rv1979c G376D | 0.0%/0.5% | |
F1067 | Isoniazid (high) | katG N218 fs | 10.7%/7.6% | |
RF021 | Pyrazinamide – testing failed | pncA Q122H | 0%/2.5% |