A genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis

Table 3 Significant SNPs assigned to candidate genes for oligosaccharide synthesis in Danish Holstein

Gene	Gene name	Chr.^b	# SNP^c	Highest -log₁₀(P-value)	PVE%^d	Trait^a
B3GNT5	UDP-GlcNAc:betaGal beta-1.3-N-acetylglucosaminyltransferase 5	1	4	20.779	24.02	3_1_0_0_0 LNT
B3GNT5	UDP-GlcNAc:betaGal beta-1.3-N-acetylglucosaminyltransferase 5	1	3	19.771	22.94	4_2_0_0_0 LNH
LOC520336	N-acetyllactosaminide beta-1.6-N-acetylglucosaminyl-transferase. Isoform C	23	2	6.318	7.34	4_2_0_0_0 LNH
ALG3	ALG3. alpha-1.3- mannosyltransferase	1	1	6.307	7.32	4_2_0_0_0 LNH
ALG3	ALG3. alpha-1.3- mannosyltransferase	1	1	5.054	5.76	3_1_0_0_0 LNT
B3GALNT2	beta-1.3-N-acetylgalactosaminyltransferase 2	28	2	5.539	6.37	5_4_0_0_0
GLT6D1	glycosyltransferase 6 domain containing 1	11	2	5.124	5.85	4_1_0_0_0

^aOligosaccharides are represented by their monosaccharide compositions, denoted as Hex_HexNAc_Fuc_NeuAc_NeuGc
^bChr chromosome
^c#SNP number of significant SNPs assigned to candidate gene
^dPVE% Percentage of phenotypic variation explained

ISSN: 1471-2164