A hypergraph-based method for large-scale dynamic correlation study at the transcriptomic scale

BMC Genomics

Table 2 Enrichment analysis of the yeast dataset for the top 15 most connected clusters

Group label	Group size	Hyperedges involved	GOBPID	Term	P-value
5	180	432	GO:0005979	regulation of glycogen biosynthetic process	1.34E-03
			GO:0016052	carbohydrate catabolic process	5.17E-03
28	46	85	GO:0032543	mitochondrial translation	2.28E-03
			GO:0072329	monocarboxylic acid catabolic process	6.64E-03
2	237	82	GO:0030154	cell differentiation	2.15E-03
			GO:0030435	sporulation resulting in formation of a cellular spore	5.63E-03
21	60	69	GO:0006259	DNA metabolic process	1.10E-09
			GO:1903047	mitotic cell cycle process	7.00E-06
12	114	61	GO:0022613	ribonucleoprotein complex biogenesis	4.25E-13
			GO:0034660	ncRNA metabolic process	1.97E-10
7	168	59	GO:0005996	monosaccharide metabolic process	7.62E-03
34	38	55	GO:0016236	macroautophagy	4.56E-03
			GO:0048193	Golgi vesicle transport	9.15E-03
22	59	52	GO:0055114	oxidation-reduction process	3.84E-05
			GO:0071822	protein complex subunit organization	2.70E-04
32	41	48	GO:0042254	ribosome biogenesis	2.77E-15
			GO:0034470	ncRNA processing	1.02E-09
53	20	48	GO:0032465	regulation of cytokinesis	1.28E-03
			GO:0045839	negative regulation of mitotic nuclear division	9.30E-03
31	43	40	GO:0000278	mitotic cell cycle	5.15E-07
			GO:0007010	cytoskeleton organization	3.73E-04
45	28	39	GO:0016054	organic acid catabolic process	1.21E-03
			GO:0015074	DNA integration	2.56E-03
29	44	36	GO:0034637	cellular carbohydrate biosynthetic process	2.43E-03
			GO:0055114	oxidation-reduction process	6.09E-03
14	96	35	GO:0006412	translation	1.64E-32
			GO:0022613	ribonucleoprotein complex biogenesis	2.99E-16
18	75	35	GO:0007030	Golgi organization	5.04E-04
			GO:0051784	negative regulation of nuclear division	2.15E-03

For each cluster, the enriched term that include the most number of genes in the cluster is shown

ISSN: 1471-2164