Comparative analysis reveals conservation in genome organization among intestinal Cryptosporidium species and sequence divergence in potential secreted pathogenesis determinants among major human-infecting species

Table 3 Putative transporters in Cryptosporidium spp. and some other common apicomplexan parasites^a

Substrates	Cellular location	Cchi	Cpar	ChomUde	Cmel	Cubi	Cbai	Cand	Cmur	Pfal	Tgon
Hexose		2	2	2	2	2	2	2	3	2	5
Triose phosphate	Plasma/Apicoplast membrane	7	8	8	8	8	7	8	8	4	4
Amino acids	Plasma membrane	10	10	10	10	10	10	12	12	1	6
Nucleobase/nucleoside	Plasma membrane	1	1	1	1	1	1	1	1	4	4
Nucleotide-sugar	Plasma membrane	3	3	3	3	3	2	2	2	1	4
Folate/pterine	Plasma membrane	1	1	2	1	1	1	1	1	2	7
Formate/nitrite		0	0	0	0	0	0	0	0	1	3
GABA (aminobutanoate)	Plasma/Mitochondrial membrane	0	0	0	0	0	0	0	0	2	5
Acetyl-CoA		1	1	1	1	1	1	1	1	1	1
Chloride		0	0	0	0	0	0	0	0	0	2
Inorganic phosphate		0	0	0	0	0	0	0	0	1	1
Sulfate		1	1	1	1	1	1	1	1	1	4
Sodium/potassium/calcium		2	2	2	2	2	2	3	3	0	9
Zinc		2	2	2	2	2	2	2	2	2	4
Copper		1	1	1	1	1	1	1	1	2	3
Choline	Plasma membrane	0	0	0	0	0	0	0	0	1	2
Cadmium/zinc/cobalt (efflux)	Plasma membrane	1	1	1	1	1	1	1	1	1	1
Glycerol/water	Plasma membrane	0	0	0	0	0	0	0	0	2	2
ABC transporter	Plasma membrane	21	21	21	21	21	22	21	21	16	24
Mitochondrial carrier	Mitochondrial membrane	8	9	9	8	6	6	13	12	14	21

Cchi Cryptosporidium chipmunk genotype I, Cpar Cryptosporidium parvum, ChomUde C. hominis UdeA01, Cmel C. meleagridis, Cubi C. ubiquitum, Cbai C. baileyi, Cand C. andersoni, Cmur C. muris, Pfal Plasmodium falciparum, Tgon Toxoplasma gondii
^aThe detection of these transporter proteins was based on the Pfam search results

ISSN: 1471-2164