Fig. 4

Identification of the genome-wide putative target genes of FOXO. a The distribution of FOXO ChIP-seq peaks in different genomic regions (left) and the proportions of the genomic regions in each category (right) were shown. b The kernel density plot of distances between peaks and TSSs ranging from − 10 Kb to 10 Kb. c The significant FOXO binding motif found in the top 500 binding peaks with smallest q-values by MEME-ChIP. d The venn diagram of the putative target genes of FOXO identified from ChIP-seq and genome-wide in silico analysis, respectively. e-f The enrichment analysis of the FOXO putative target genes were performed based on GO terms in the biological process category (e) and KEGG pathways (f), in which the circle size corresponds to gene number