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Table 1 Ingenuity Pathway Analysis of endometrial genes differentially expressed at week 5

From: Concurrent and long-term associations between the endometrial microbiota and endometrial transcriptome in postpartum dairy cows

Pathway or Biological Function

Z-score

P-value

Cyclic vs non-cyclic (n = 809 DEG)

 Canonical Pathway - Decreased

  EIF2 signaling (i.e., protein synthesis)

 

6.16E-10

 Biological Functions - Increased

  Transport of molecule

2.809

5.01E-05

  Transport of lipid

2.753

7.24E-03

  Oxidation of lipid

2.325

5.03E-03

  Quantity of carbohydrate

2.057

1.72E-04

  Cell-cell contact

2.295

5.25E-03

  Fusion of cells

2.266

2.02E-03

  Formation of muscle

2.209

3.63E-03

  Head and neck cancer

2.4

6.69E-03

 Biological Functions - Decreased

  Cell death

−2.193

2.11E-03

  Necrosis

− 2.493

2.45E-03

  Astrocytosis

−2.353

3.53E-03

  Liver lesion

−2.452

1.71E-04

Week 1 microbiota (WK1_PC1; n = 516 DEG)

 Biological functions - Increased

  Thoracic hypoplasia

2.44

1.73E-05

  Cardiac lesion

2.423

8.65E-03

  Fibrosis of heart

2.241

6.66E-03

 Biological functions - Decreased

  Organization of cytoplasm

−2.383

1.32E-03

  Organization of cytoskeleton

−2.383

1.41E-03

  Proliferation of neuroblastoma cell lines

−2.412

6.95E-03

  Formation of muscle cells

−2.607

4.07E-04

  Formation of muscle

−2.902

2.44E-04

Week 5 microbiota (WK5_PC1; n = 96 DEG)

 Biological functions - Decreased

  Organismal death

−2.35

3.58E-03

  Thoracic hypoplasia

−2

7.07E-03