Table 3 Differentially regulated pathways between gorilla and humans identified using Ingenuity Pathway Analysis
From: Mapping gastrointestinal gene expression patterns in wild primates and humans via fecal RNA-seq
Ingenuity Canonical Pathways | -log(p-value) | Ratio | z-score | Molecules |
|---|---|---|---|---|
Oxidative Phosphorylation | 6.02E+ 00 | 8.26E-02 | 3 | COX6B1,SDHB,ATP5PD,COX5B,ATP5MF,ATP5MC3,UQCRQ,ATP5F1E,UQCRB |
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes | 2.72E+ 00 | 5.38E-02 | 2.236 | FCGR2A,ACTB,ARPC3,ACTC1,ACTA1 |
Dendritic Cell Maturation | 1.42E+ 00 | 2.58E-02 | 2.236 | PLCD3,NFKBIA,LEP,FCGR2A,IL32 |
Interferon Signaling | 3.44E+ 00 | 1.11E-01 | 2 | IFNGR2,IFI6,IFITM2,IFITM1 |
PI3K Signaling in B Lymphocytes | 1.39E+ 00 | 2.94E-02 | 2 | PLCD3,ATF3,NFKBIA,CHP1 |
EIF2 Signaling | 9.25E+ 00 | 7.05E-02 | 1.89 | ATF3,ACTB,RPS23,RPLP2,RPL23,RPL10A,RPS28,EIF1,RPS13,RPS25,RPS15A,RPL36,RPL31,ACTC1,ACTA1,RPLP0 |
RhoA Signaling | 3.74E+ 00 | 5.65E-02 | 1.633 | ARHGEF12,NRP2,CFL1,ACTB,ARPC3,ACTC1,ACTA1 |
Regulation of Actin-based Motility by Rho | 4.63E+ 00 | 7.78E-02 | 1.342 | RHOB,CFL1,ACTB,ARPC3,GSN,ACTC1,ACTA1 |
HMGB1 Signaling | 1.98E+ 00 | 3.60E-02 | 1.342 | HMGB1,CXCL8,KAT6B,RHOB,IFNGR2 |
Integrin Signaling | 3.60E+ 00 | 4.11E-02 | 1.134 | ARF5,RHOB,ACTB,ARPC3,ZYX,CAPN2,GSN,ACTC1,ACTA1 |
Signaling by Rho Family GTPases | 3.16E+ 00 | 3.57E-02 | 1.134 | GNB1,CDH1,ARHGEF12,RHOB,CFL1,ACTB,ARPC3,ACTC1,ACTA1 |
ILK Signaling | 2.56E+ 00 | 3.55E-02 | 1.134 | PPP2CB,CDH1,RHOB,CFL1,ACTB,ACTC1,ACTA1 |
Actin Cytoskeleton Signaling | 4.10E+ 00 | 4.29E-02 | 1 | ARHGEF12,WASF2,CFL1,ACTB,FGF23,ARPC3,GSN,ACTC1,ACTA1,IQGAP3 |
Dopamine-DARPP32 Feedback in cAMP Signaling | 3.01E+ 00 | 4.27E-02 | 1 | PLCD3,PPP2CB,KCNJ2,KCNJ14,CHP1,PPP1R11,KCNJ3 |
Death Receptor Signaling | 1.93E+ 00 | 4.30E-02 | 1 | NFKBIA,ACTB,ACTC1,ACTA1 |
Tec Kinase Signaling | 1.64E+ 00 | 2.94E-02 | 1 | GNB1,RHOB,ACTB,ACTC1,ACTA1 |
Sirtuin Signaling Pathway | 2.16E+ 00 | 2.74E-02 | 0.816 | SCNN1A,CXCL8,CDH1,SDHB,SLC2A1,TUBA4B,HMGCS2,ATP5F1E |
Neuroinflammation Signaling Pathway | 1.12E+ 00 | 1.93E-02 | 0.447 | HMGB1,CXCL8,CHP1,IFNGR2,GLUL,KCNJ3 |
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 1.42E+ 00 | 2.58E-02 | −0.447 | PPP2CB,NFKBIA,RHOB,IFNGR2,PPP1R11 |
Phospholipase C Signaling | 1.54E+ 00 | 2.46E-02 | −0.816 | GNB1,PLCD3,ARHGEF12,RHOB,FCGR2A,CHP1 |
RhoGDI Signaling | 5.12E+ 00 | 5.65E-02 | −1 | GNB1,CDH1,ARHGEF12,WASF2,RHOB,CFL1,ACTB,ARPC3,ACTC1,ACTA1 |
Gαq Signaling | 1.73E+ 00 | 3.11E-02 | −1 | GNB1,RGS2,NFKBIA,RHOB,CHP1 |
IL-8 Signaling | 1.35E+ 00 | 2.46E-02 | −1 | GNB1,CXCL8,CDH1,RHOB,LASP1 |