Table 4 Main biological functions associated with DE genes in the OR semispecies^a

 Acsl

Acyl-CoA synthetase long-chain

D

 ATPCL

ATP citrate lyase

D

 CDase

Ceramidase

D

 Hmgs

HMG Coenzyme A synthase

D

 Jhe

Juvenile hormone esterase

D

 mag

magro

D

 Sc2

Sc2

D

 bgm

bubblegum

D

D

 mino

minotaur

D

D

 sPLA2

secretory Phospholipase A2

D

D

 Unannotated

22 unannotated genes with homologs in D. melanogaster

D/ U

D

D

 wal

walrus

D

 yip2

yippee interacting protein 2

D

 FarO

Fatty acyl-CoA reductase in oenocytes

U

 ade2

adenosine 2

D

 Prat2

Phosphoribosylamidotransferase 2

D

 Unannotated

2 unannotated genes with homologs in D. melanogaster

D

 Uro

Urate oxidase

U

 Hn

Henna

D

 ppl

pumpless

D

 Ssadh

Succinic semialdehyde dehydrogenase

D

 Unannotated

6 unannotated genes with homologs in D. melanogaster

D

D

D

 Ahcy

Adenosylhomocysteinase

D

D

 Sardh

Sarcosine dehydrogenase

D

D

 Shmt

Serine hydroxymethyl transferase

D

D

 Spat

Serine pyruvate aminotransferase

D

D

 aay

astray

D

 CG8129

no_fullname

D

 Nmdmc

NAD-dependent methylenetetrahydrofolate dehydrogenase

D

 P5cr-2

Pyrroline-5-carboxylate reductase-like 2

D

 mnd

minidiscs

D

 Gnmt

Glycine N-methyltransferase

D

 Gs2

Glutamine synthetase 2

U

 Ilp8

Insulin-like peptide 8

D

 LManIII

Lysosomal alpha-mannosidase III

D

 LManVI

Lysosomal alpha-mannosidase VI

D

 AkhR

Adipokinetic hormone receptor

D

 Galk

Galactokinase

D

 Ilp2

Insulin-like peptide 2

D

 Taldo

Transaldolase

D

D

 AcCoAS

Acetyl Coenzyme A synthase

D

D

D

 Hex-C

Hexokinase C

D

D

D

 Idgf6

Imaginal disc growth factor 6

D

D

D

 Mdh1

Malate dehydrogenase 1

D

D

D

 Unannotated

9 unannotated genes with homologs in D. melanogaster

D

D

D

 LManII

Lysosomal alpha-mannosidase II

D

D

 pug

pugilist

D

D

 Pepck

Phosphoenolpyruvate carboxykinase

D

 Amyrel

Amyrel

D

 Cht4

Chitinase 4

D

 Mal-A4

Maltase A4

D

 InR

Insulin-like receptor

U

 LManI

Lysosomal alpha-mannosidase I

U

 Cda5

Chitin deacetylase-like 5

U

U

 kdn

knockdown

U

U

 rgn

regeneration

U

U

 Idgf4

Imaginal disc growth factor 4

U

 boss

bride of sevenless

U

 LUBEL

Linear Ubiquitin E3 ligase

D

D

 26-29-p

26-29kD-proteinase

D

 Ance

Angiotensin converting enzyme

D

 cathD

cathD

D

 iotaTry

iotaTrypsin

D

 CtsB1

Cathepsin B1

D

D

 Acer

Angiotensin-converting enzyme-related

D

D

 Ance-5

Ance-5

D

D

 Unannotated

30 unannotated genes with homologs in D. melanogaster

D/ U

D

D

D

 gol

goliath

D

 Jon99Ci

Jonah 99Ci

D

D

 Ance-3

Ance-3

D

 Bace

beta-site APP-cleaving enzyme

D

 CG13025

no_fullname

U

 CG2224

no_fullname

U

 dmpd

dampened

U

 e(y)2b

enhancer of yellow 2b

U

 Jon65Aiv

Jonah 65Aiv

U

 Jon66Cii

Jonah 66Cii

U

 Npl4

Nuclear protein localization 4

U

 SP1029

SP1029

U

 Usp30

Ubiquitin specific protease 30

U

 epsilonTry

epsilonTrypsin

U

U

 Prosalpha4

Proteasome alpha4 subunit

U

 Rel

Relish

D

 Glt

Glutactin

D

D

 GNBP-like3

GNBP-like 3

D

D

 MP1

Melanization Protease 1

D

D

 GNBP2

Gram-negative bacteria binding protein 2

D

 Tsf1

Transferrin 1

D

 SPE

Spatzle-Processing Enzyme

D

D

 Spn28Dc

Serpin 28Dc

D

D

 yellow-f2

yellow-f2

D

D

D

 casp

caspar

D

 Hsp27

Heat shock protein 27

D

 PPO2

Prophenoloxidase 2

D

 CBP

sarcoplasmic calcium-binding protein

D

 Dlip3

Dorsal interacting protein 3

D

 Hat1

Histone acetyltransferase 1

D

 heix

heixuedian

D

 Unannotated

4 unannotated genes with homologs in D. melanogaster

U

D

U/ D

D

 AttA

Attacin-A

U

 LysD

Lysozyme D

U

 Lmpt

Limpet

U

U

 AttD

Attacin-D

U

U

 DptB

Diptericin B

U

U

 AttC

Attacin-C

U

 e

ebony

U

 edin

elevated during infection

U

 Fer2LCH

Ferritin 2 light chain homologue

U

 Fuca

alpha-L-fucosidase

U

 pirk

poor Imd response upon knock-in

U

 Tep3

Thioester-containing protein 3

U

 Tep4

Thioester-containing protein 4

U

 yellow-b

yellow-b

U

 Est-6

Esterase 6

D

D

 Obp56a

Odorant-binding protein 56a

D

D

 Obp99c

Odorant-binding protein 99c

D

D

 Obp56g

Odorant-binding protein 56g

D

 Obp56h

Odorant-binding protein 56h

D

 Obp83ef

Odorant-binding protein 83ef

D

 Obp99b

Odorant-binding protein 99b

D

D

 Obp56d

Odorant-binding protein 56d

U

D

D

 ninaD

neither inactivation nor afterpotential D

D

 chp

chaoptin

U

 eys

eyes shut

U

 Fbxl4

F box and leucine-rich-repeat gene 4

U

 ninaC

neither inactivation nor afterpotential C

U

 ninaG

neither inactivation nor afterpotential G

U

 norpA

no receptor potential A

U

 prom

prominin

U

 Desat2

Desaturase 2

D

 FASN1

Fatty acid synthase 1

D

 FASN2

Fatty acid synthase 2

D

 Fbp2

Fat body protein 2

D

 Fbp1

Fat body protein 1

D

D

 alphaTub67C

alpha-Tubulin at 67C

D

 aPKC

atypical protein kinase C

D

 BicC

Bicaudal C

D

 cad

caudal

D

 CDC45L

CDC45L

D

 cort

cortex

D

 CycB3

Cyclin B3

D

 dhd

deadhead

D

 egg

eggless

D

 exu

exuperantia

D

 fs(1)Ya

female sterile (1) Young arrest

D

 Fs(2)Ket

Female sterile (2) Ketel

D

 fzy

fizzy

D

 gcl

germ cell-less

D

 Grip84

Gamma-tubulin ring protein 84

D

 gus

gustavus

D

 hop

hopscotch

D

 lok

loki

D

 Mcm10

Minichromosome maintenance 10

D

 Mer

Merlin

D

 Mos

Mos oncogene

D

 nos

nanos

D

 pbl

pebble

D

 Pen

Pendulin

D

 pie

pineapple eye

D

 png

pan gu

D

 polo

polo

D

 slam

slow as molasses

D

 spd-2

spindle defective 2

D

 ssh

slingshot

D

 stai

stathmin

D

 swa

swallow

D

 tor

torso

D

 Tre1

Trapped in endoderm 1

D

 twe

twine

D

 Xpc

Xeroderma pigmentosum%2C complementation group C

D

 asp

abnormal spindle

D

 cmet

CENP-meta

D

 spn-E

spindle E

D

 Mdr49

Multi drug resistance 49

D

 Rab1

Rab1

D

 kug

kugelei

U

 Doa

Darkener of apricot

U

U

 bond

james bond

U

 c(3)G

crossover suppressor on 3 of Gowen

U

 LanA

Laminin A

U

 antr

antares

D

 aqrs

aquarius

D

 CHOp24

CHOp24

D

 Esp

Epidermal stripes and patches

D

 to

takeout

D

 EbpIII

Ejaculatory bulb protein III

U

D

D

D

 Fkbp14

FK506-binding protein 14

D

 Mical

Molecule interacting with CasL

U

 SERCA

Sarco/endoplasmic reticulum Ca(2+)-ATPase

U

 sesB

stress-sensitive B

U

 skd

skuld

U

 Actn

alpha actinin

U

U

 bt

bent

U

U

 clumsy

Clumsy

U

U

 fln

flightin

U

U

 Mhc

Myosin heavy chain

U

U

 Mhcl

Myosin heavy chain-like

U

U

 Mlc1

Myosin alkali light chain 1

U

U

 Mlc2

Myosin light chain 2

U

U

 Mlp60A

Muscle LIM protein at 60A

U

U

 Msp300

Muscle-specific protein 300 kDa

U

U

 shot

short stop

U

U

 Tm2

Tropomyosin 2

U

U

 tn

thin

U

U

 TpnC4

Troponin C isoform 4

U

U

 uif

uninflatable

U

U

 Unannotated

28 unannotated genes with homologs in D. melanogaster

U

U

 Unc-89

Unc-89

U

U

 up

upheld

U

U

 vkg

viking

U

U

 Zasp52

Z band alternatively spliced PDZ-motif protein 52

U

U

 Alk

Anaplastic lymphoma kinase

U

 CAP

CAP

U

 chas

chascon

U

 Col4a1

Collagen type IV alpha 1

U

 eya

eyes absent

U

 Grip

Glutamate receptor binding protein

U

 if

inflated

U

 Mlp84B

Muscle LIM protein at 84B

U

 Neurochondrin

Neurochondrin

U

 RyR

Ryanodine receptor

U

 sals

sarcomere length short

U

 TpnC73F

Troponin C at 73F

U

 Zasp66

Z band alternatively spliced PDZ-motif protein 66

U

 Tfb4

Transcription factor B4

D

 eEF1gamma

eukaryotic translation elongation factor 1 gamma

D

 eEF2

eukaryotic translation elongation factor 2

D

 eEF5

eukaryotic translation elongation factor 5

D

 Rack1

Receptor of activated protein kinase C 1

D

 sta

stubarista

D

 eEF1alpha1

eukaryotic translation elongation factor 1 alpha 1

D

D

 RpL/ RpS

28 Ribosomal proteins

D

D

D

 eEF1alpha2

eukaryotic translation elongation factor 1 alpha 2

U

U

 Cyp311a1

Cyp311a1

D

 Cyp4e2

Cytochrome P450-4e2

D

 Cyp6a8

Cytochrome P450-6a8

D

 Cyp6d2

Cyp6d2

D

 Cyp12a4

Cyp12a4

D

 Cyp12d1-p

Cyp12d1-p

D

 Cyp6t1

Cyp6t1

D

 Cyp309a2

Cyp309a2

D

D

 Cyp6g1

Cyp6g1

D

D

 Cyp4p3

Cyp4p3

D

D

D

 Cyp6d5

Cyp6d5

D

D

D

 Cyp4ac2

Cyp4ac2

D

 Cyp4e3

Cytochrome P450-4e3

U

 Yp1

Yolk protein 1

D

 Yp2

Yolk protein 2

D

 Yp3

Yolk protein 3

D