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Fig. 5 | BMC Genomics

Fig. 5

From: Identifying genetic determinants of complex phenotypes from whole genome sequence data

Fig. 5

Analysis of the P.aeruginosa data across the 26 strains from [25]. The distributions of MIC values (on a log2 scale) are shown for a Ciprofloxacin, b Ceftazidime, and c Gentamicin. These empirical distributions were used to determine MIC thresholds for the AB analyses (Table 2). Note that the scales on the y-axis vary slightly. With RRF, a throughout search of the discretization was performed to select thresholds θ1 / θ2 that would minimize the Out-of-bag error for d Ciprofloxacin, e Ceftazidime, and f Gentamicin (color scale to the right of each panel). The θ1 / θ2 combinations (red dotted lines, also reported in first row) were determined visually. The top 10% most important sites (as per their Gini index) are highlighted (box with broken lines) among sites selected at the end of the first tier of the chunking algorithm for g Ciprofloxacin, h Ceftazidime, and i Gentamicin. These top sites are listed in the top right part of each distribution

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