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Fig. 5 | BMC Genomics

Fig. 5

From: West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles

Fig. 5

Effect of WNV infection on composition of EVs RNA cargo involves IFN-dependent and IFN-independent mechanisms. Venn diagrams (a-c) representing common and unique differentially expressed miRNAs (a), sncRNAs (b) and mRNAs (c) identified in EVs secreted by WNV-infected and IFN-treated cells. Bar plots (d-f) demonstrate the effect of WNV infection on abundance of mRNAs (d), sncRNAs (e) and mRNAs (f) in EVs secreted by IFN-competent (WT A549) and IFN-deficient (A549/BVDV-Npro) cells. RNA abundance was determined by qRT-PCR. Fold change was calculated relative to RNA levels in EVs from mock-treated A549 or A549/BVDV-Npro cells with normalisation to miR-30 (d) or SNORD37(e, f). Values in (d-f) are the means of 3 biological replicates ±SD. Dash line indicates RNA levels in EVs from mock-treated cells

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BMC Genomics

ISSN: 1471-2164

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