Fig. 3

The essence of the altered “cumulome” after maturation in vitro. Schematic view on aberrant metabolism in cumulus cells after maturation in vitro compared to maturation in vivo. Mapped are 91 compounds with significantly different abundance in in vitro matured cumulus (78 proteins and 21 metabolites, full names are listed in Table 2). Relevant related proteins, metabolites or pathways not detected in this study were imputed (dashed lines). Items with higher abundance after maturation in vitro are coloured in purple, items with lower abundance in green. Circles surround proteins and hexagons metabolites