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Fig. 2 | BMC Genomics

Fig. 2

From: Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks

Fig. 2

Module characterisation. a Dendrogram showing hierarchical clustering of lncRNAs based on MCA score profile. Branches of the dendrogram correspond to modules, with lncRNAs in each module assigned the same colour (indicated by the colour band below the dendrogram). LncRNAs not assigned to a module are coloured grey. b Clustering dendrograms of module eigen-lncs. Meta-modules are defined at height cut-off of 0.80 and indicated by different colours. Below the dendrogram, functional and cell type signatures of each module are indicated, with green corresponding to significant positive enrichment and red to significant negative enrichment. c. Bubble chart showing cancer type specificity of each module. Size of bubble indicates the proportion of module-associated lncRNAs that meet the expression detection threshold in each cancer type. Red bubbles indicate outlier cancer types (> 1.5 times the interquartile range above the upper quartile). A description of the cancer type codes is given in Additional file 4: Table S1

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