Table 1 Estimated type-1 error rates with simulation data based on Nigerian people’s RNA-seq data. Estimated type-1 error rates by BALLI, DESeq2, edgeR, LLI, and voom and their 95% confidence levels were estimated for N = 12,16,20 and 24. aThe type-1 error rates are marked by bold font if their 95% confidence levels include or lower than the nominal significant level α
BALLI | DESeq2 | edgeR | LLI | voom | BALLI | DESeq2 | edgeR | LLI | voom | |
|---|---|---|---|---|---|---|---|---|---|---|
α | N = 12 | N = 16 | ||||||||
0.1 | 0.09217 a (0.08173,0.10262) | 0.08221 (0.07144,0.09298) | 0.10536 (0.09595,0.11477) | 0.12695 (0.11443,0.13947) | 0.09381 (0.08306,0.10456) | 0.08976 (0.08033,0.09919) | 0.08794 (0.07827,0.09761) | 0.11070 (0.10223,0.11916) | 0.11613 (0.10522,0.12704) | 0.09618 (0.08683,0.10552) |
0.05 | 0.04485 (0.03814,0.05155) | 0.04374 (0.03633,0.05115) | 0.05495 (0.04877,0.06114) | 0.06636 (0.05767,0.07506) | 0.04473 (0.03798,0.05148) | 0.04329 (0.03764,0.04895) | 0.04672 (0.04041,0.05302) | 0.05762 (0.05218,0.06305) | 0.06072 (0.05355,0.06790) | 0.04645 (0.04078,0.05212) |
0.01 | 0.00899 (0.00686,0.01112) | 0.01208 (0.00913,0.01503) | 0.01441 (0.01186,0.01697) | 0.01662 (0.01328,0.01996) | 0.00860 (0.00653,0.01066) | 0.00796 (0.00643,0.00948) | 0.01202 (0.00980,0.01424) | 0.01393 (0.01212,0.01575) | 0.01349 (0.01118,0.01580) | 0.00850 (0.00706,0.00993) |
0.005 | 0.00456 (0.00328,0.00584) | 0.00741 (0.00531,0.00952) | 0.00891 (0.00709,0.01072) | 0.00942 (0.00720,0.01163) | 0.00424 (0.00301,0.00548) | 0.00381 (0.00305,0.00458) | 0.00695 (0.00555,0.00835) | 0.00809 (0.00692,0.00925) | 0.00714 (0.00575,0.00853) | 0.00397 (0.00326,0.00468) |
α | N = 20 | N = 24 | ||||||||
0.1 | 0.08698 (0.07689,0.09707) | 0.08700 (0.07653,0.09747) | 0.10962 (0.10028,0.11896) | 0.10564 (0.09442,0.11686) | 0.09289 (0.08246,0.10332) | 0.08480 (0.07651,0.09309) | 0.08744 (0.07802,0.09686) | 0.10874 (0.10024,0.11724) | 0.10067 (0.09133,0.11000) | 0.09124 (0.08196,0.10051) |
0.05 | 0.04113 (0.03455,0.04771) | 0.04607 (0.03870,0.05344) | 0.05774 (0.05147,0.06401) | 0.05408 (0.04633,0.06183) | 0.04517 (0.03844,0.05191) | 0.03919 (0.03450,0.04387) | 0.04518 (0.03922,0.05114) | 0.05881 (0.05343,0.06419) | 0.04960 (0.04402,0.05519) | 0.04390 (0.03849,0.04931) |
0.01 | 0.00752(0.00548,0.00955) | 0.01175 (0.00890,0.01460) | 0.01381 (0.01152,0.01609) | 0.01157 (0.00879,0.01436) | 0.00848 (0.00643,0.01053) | 0.00647 (0.00550,0.00744) | 0.01050 (0.00873,0.01228) | 0.01317 (0.01163,0.01472) | 0.00955 (0.00817,0.01093) | 0.00778 (0.00648,0.00907) |
0.005 | 0.00368 (0.00248,0.00489) | 0.00669 (0.00475,0.00863) | 0.00789 (0.00643,0.00934) | 0.00605 (0.00428,0.00783) | 0.00420 (0.00305,0.00535) | 0.00293 (0.00248,0.00338) | 0.00575 (0.00477,0.00672) | 0.00728 (0.00636,0.00819) | 0.00474 (0.00400,0.00547) | 0.00363 (0.00295,0.00431) |