Fig. 1From: Assessing cell-specific effects of genetic variations using tRNA microarraysGeneral model of mRNA translation. The rate of translation for each codon depends on the collision of tRNAs with the ribosome (gray) and is proportional to cellular concentration of the cognate tRNA isoacceptor [75]. Codons pairing to low-abundance tRNAs (blue) exhibit slower velocity than codons pairing to high-abundance tRNAs (red), which are translated more rapidlyBack to article page