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Table 1 Ion channel genes in the zebra finch genome

From: Exploring the molecular basis of neuronal excitability in a vocal learner

HGNC Symbol Alternate name Full name Zebra finch locus
A. Sodium channels
α subunits
  SCN1A Nav1.1 sodium voltage-gated channel alpha subunit 1 ENSTGUG00000007356^
  SCN2A Nav1.2 sodium voltage-gated channel alpha subunit 2 ENSTGUG00000007152^*
  SCN3A Nav1.3 sodium voltage-gated channel alpha subunit 3 ENSTGUG00000007034
  SCN4A Nav1.4 sodium voltage-gated channel alpha subunit 4 ENSTGUG00000003230
  SCN5A Nav1.5 sodium voltage-gated channel alpha subunit 5 ENSTGUG00000000531^
ENSTGUG00000000533^
  SCN8A Nav1.6 sodium voltage-gated channel alpha subunit 8 ENSTGUG00000003307
  SCN9A Nav1.7 sodium voltage-gated channel alpha subunit 9 ENSTGUG00000007470^*
  SCN10A Nav1.8 sodium voltage-gated channel alpha subunit 10 ENSTGUG00000000476^*
  SCN11A Nav1.9 sodium voltage-gated channel alpha subunit 11 chr2:5686797–5,719,627
β subunits
  SCN1B$   sodium voltage-gated channel beta subunit 1 MUGN01000920.1818309–818,447
  SCN2B   sodium voltage-gated channel beta subunit 2 ENSTGUG00000017358
MUGN01000074.12766152–2,766,960
  SCN3B   sodium voltage-gated channel beta subunit 3 ENSTGUG00000000607^
  SCN4B   sodium voltage-gated channel beta subunit 4 ENSTGUG00000000230
MUGN01000074.12777132–2,778,696
Acid-sensing
  ASIC1 ACCN2 acid sensing ion channel subunit 1 ENSTGUG00000003637
  ASIC2# ACCN1 acid sensing ion channel subunit 2 ENSTGUG00000003212^*
ENSTGUG00000003215^*
  ASIC3 ACCN3 acid sensing ion channel subunit 3 ENSTGUG00000016020^*
MUGN01000217.1876923–883,599
  ASIC4 ACCN4 acid sensing ion channel subunit 4 ENSTGUG00000006157*
  ASIC5 ACCN5 acid sensing ion channel subunit 5 ENSTGUG00000005392
Leak channel
  NALCN   sodium leak channel, non selective ENSTGUG00000010876
Epithelial
  SCNN1A$ SCNN1 sodium channel epithelial 1 alpha subunit ENSTGUG00000013342*
  SCNN1B   sodium channel epithelial 1 beta subunit ENSTGUG00000005936
  SCNN1D   sodium channel epithelial 1 delta subunit ENSTGUG00000004091
  SCNN1G   sodium channel epithelial 1 gamma subunit chr14:8747853–8,755,433
B. Calcium channels
L-type α subunits
  CACNA1S Cav1.1 calcium voltage-gated channel subunit alpha1 S ENSTGUG00000001142*
  CACNA1C Cav1.2 calcium voltage-gated channel subunit alpha1 C ENSTGUG00000012529^
ENSTGUG00000012538^
  CACNA1D Cav1.3 calcium voltage-gated channel subunit alpha1 D ENSTGUG00000006839*
  CACNA1F Cav1.4 calcium voltage-gated channel subunit alpha1 F MUGN01000244.140490–59,194
N/P/Q/R- type α subunits
  CACNA1A Cav2.1 calcium voltage-gated channel subunit alpha1 A MUGN01001147.1274884–306,034
  CACNA1B Cav2.2 calcium voltage-gated channel subunit alpha1 B ENSTGUG00000002855*
  CACNA1E Cav2.3 calcium voltage-gated channel subunit alpha1 E ENSTGUG00000017352
T-type α subunits
  CACNA1G Cav3.1 calcium voltage-gated channel subunit alpha1 G ENSTGUG00000009049*
  CACNA1H Cav3.2 calcium voltage-gated channel subunit alpha1 H ENSTGUG00000006881*
  CACNA1I Cav3.3 calcium voltage-gated channel subunit alpha1 I ENSTGUG00000010198*
α2/δ subunits
  CACNA2D1   calcium voltage-gated channel auxiliary subunit alpha2delta 1 ENSTGUG00000002536^*
ENSTGUG00000002533^*
  CACNA2D2   calcium voltage-gated channel auxiliary subunit alpha2delta 2 ENSTGUG00000004703^*
ENSTGUG00000004711^*
ENSTGUG00000004714^*
  CACNA2D3   calcium voltage-gated channel auxiliary subunit alpha2delta 3 ENSTGUG00000006966^*
  CACNA2D4   calcium voltage-gated channel auxiliary subunit alpha2delta 4 ENSTGUG00000012579^
β subunits
  CACNB1   calcium voltage-gated channel auxiliary subunit beta 1 MUGN01000261.12481145–2,492,038
  CACNB2   calcium voltage-gated channel auxiliary subunit beta 2 ENSTGUG00000001247*
  CACNB3   calcium voltage-gated channel auxiliary subunit beta 3 ENSTGUG00000015546
MUGN01000394.1996686–999,415
  CACNB4   calcium voltage-gated channel auxiliary subunit beta 4 ENSTGUG00000012082^*
γ subunits
  CACNG1   calcium voltage-gated channel auxiliary subunit gamma 1 ENSTGUG00000004397^
  CACNG2 stargazer, calcium voltage-gated channel auxiliary subunit gamma 2 ENSTGUG00000010725
stargazin
  CACNG3   calcium voltage-gated channel auxiliary subunit gamma 3 ENSTGUG00000006208*
  CACNG4   calcium voltage-gated channel auxiliary subunit gamma 4 ENSTGUG00000004385*
  CACNG5   calcium voltage-gated channel auxiliary subunit gamma 5 ENSTGUG00000004375*
  CACNG7$   calcium voltage-gated channel auxiliary subunit gamma 7 MUGN01000421.1339861–356,707
  CACNG8$   calcium voltage-gated channel auxiliary subunit gamma 8 MUGN01000421.1325281–333,090
Intracellular
  ITPR1 IP3R1 inositol 1,4,5-trisphosphate receptor type 1 ENSTGUG00000010241^
  ITPR2 IP3R2 inositol 1,4,5-trisphosphate receptor type 2 ENSTGUG00000012196^
  ITPR3 IP3R3 inositol 1,4,5-trisphosphate receptor type 3 ENSTGUG00000001798
  RYR1   ryanodine receptor 1 ENSTGUG00000016333^
MUGN01000615.12737–83,931
  RYR2   ryanodine receptor 2 ENSTGUG00000010491
  RYR3   ryanodine receptor 3 ENSTGUG00000011653^
  TPCN1 TPC1 two pore segment channel 1 ENSTGUG00000009086
  TPCN2 TPC2 two pore segment channel 2 ENSTGUG00000005328
  TPCN3 TPC3 two pore segment channel 3 ENSTGUG00000007338^*
ENSTGUG00000015038^*
Sperm associated
  CATSPERB C14orf161 cation channel sperm associated auxiliary subunit beta MUGN01001095.110976025–10,976,136
  CATSPERD$ TMEM146 cation channel sperm associated auxiliary subunit delta MUGN01000898.110200480–10,200,746
  CATSPERE C1orf101 catsper channel auxiliary subunit epsilon ENSTGUG00000008288^*
MUGN01000667.120007852–20,020,082
  CATSPER3   cation channel sperm associated 3 chr13_random:2493868–2,500,983
MUGN01000154.1512621–517,332
C. Chloride channels
CLCNs
  CLCN1 CLC1 chloride voltage-gated channel 1 ENSTGUG00000013222*
  CLCN2 CLC2 chloride voltage-gated channel 2 ENSTGUG00000010323*
  CLCN3 CLC3 chloride voltage-gated channel 3 ENSTGUG00000006161
  CLCN4 CLC4 chloride voltage-gated channel 4 ENSTGUG00000008365
  CLCN5$ CLC5 chloride voltage-gated channel 5 ENSTGUG00000005324
  CLCN6 CLC6 chloride voltage-gated channel 6 ENSTGUG00000002366*
  CLCN7 CLC7 chloride voltage-gated channel 7 ENSTGUG00000004211*
  CLCNK CLCK1 chloride voltage-gated channel K ENSTGUG00000002023^*
  BSND BART, DFNB73 barttin CLCNK type accessory beta subunit A chr8:22970234:22970413
CLICs
  CLIC2# CLIC2b chloride intracellular channel 2 ENSTGUG00000004925
  CLIC3$   chloride intracellular channel 3 ENSTGUG00000002341*
  CLIC4 CLIC4L chloride intracellular channel 4 ENSTGUG00000001132^*
  CLIC5   chloride intracellular channel 5 ENSTGUG00000013246
  CLIC6 CLIC1L chloride intracellular channel 6 ENSTGUG00000004696
MUGN01000638.1213150–238,240
  CLCC1 MCLC chloride channel CLIC like 1 ENSTGUG00000004508*
Calcium-activated
  ANO1 TMEM16A anoctamin 1 ENSTGUG00000005385*
  ANO2 TMEM16B anoctamin 2 ENSTGUG00000011938
  ANO3 TMEM16C anoctamin 3 ENSTGUG00000004669
  ANO4 TMEM16D anoctamin 4 ENSTGUG00000009008
  ANO5 TMEM16E anoctamin 5 ENSTGUG00000004532*
  ANO6 TMEM16F anoctamin 6 ENSTGUG00000006024*
  ANO7 TMEM16G anoctamin 8 MUGN01000068.1571318–573,272
  ANO8 TMEM16H anoctamin 8 ENSTGUG00000015909^*
  ANO9 TMEM16J anoctamin 9 ENSTGUG00000006753
  ANO10 TMEM16K anoctamin 10 ENSTGUG00000003830
  BEST1 VMD2 bestrophin 1 ENSTGUG00000005934^*
  BEST3 VMD2L3 bestrophin 3 ENSTGUG00000006968^
Volume regulated
  LRRC8A LRRC8 leucine rich repeat containing 8 VRAC subunit A ENSTGUG00000004233
  LRRC8B   leucine rich repeat containing 8 VRAC subunit B ENSTGUG00000006230*
  LRRC8C   leucine rich repeat containing 8 VRAC subunit C ENSTGUG00000006226
  LRRC8D LRRC5 leucine rich repeat containing 8 VRAC subunit D ENSTGUG00000006223
Other
  CFTR   cystic fibrosis transmembrane conductance regulator ENSTGUG00000004828
  CLNS1A   chloride nucleotide-sensitive channel 1A ENSTGUG00000013030^
  1. Highly partial or truncated
  2. Suggested name (not clear whether this locus is orthologous to mammalian CLCNKA or CLCNKB)
  3. $ Synteny traced through phylogenetic relationships
  4. # Synteny could not be linked through phylogenetic relationship
  5. Non-human ortholog used to find locus
  6. No human ortholog
  7. * Less than 90% of post-recovery length
  8. ^ Annotated as a “novel gene” in Ensembl