Fig. 5

High degree of replication in cell-based SB mutagenesis screens. The vemurafenib resistance screen was replicated by three different individuals spanning a period of several months. The gCIS2 results were obtained for each independent replicate and compared to the results obtained by analyzing the combined data set. Of the nine vemurafenib resistance driver genes identified by analyzing the entire data set, six were identified by analyzing each replicate independently while the remaining three genes (indicated with asterisks) were identified in two of the three replicates