Fig. 4

H3K27ac and H3K4me3 exhibit tissue-specific profiles in IGN and SOM. a Distribution of H3K27ac and H3K4me3 peaks across chromosomes relative to chromosome length for IGN- or SOM-H3K27ac ChIP-seq and IGN- or SOM-H3K4me3 ChIP-seq datasets. Statistically significant deviations from the expected value of 1 (indicated by black line) are indicated by asterisks (Pearson’s chi-square test, p-value< 1 × 10^− 3 [**], p-value< 1 × 10^− 10 [***]). (b and c) Metagene analysis of the distribution of average IGN- and SOM-H3K27ac ChIP-seq signal (b) and IGN- and SOM-H3K4me3 ChIP-seq signal (c) across bodies of genes in indicated categories [13]. d Example ChIP-seq and RNA-seq tracks across the IGN-specific genes csr-1 and prg-1 and SOM-specific genes dpyd-1 and prx-5. IGN signals are indicated in red and SOM signals are indicated in blue. Scale bars, 1 kb