Fig. 9

Evolution of sex-specific alternative splicing regulation of dsx and fru gene. a Comparative schematic representation of sex-specifically regulated regions of dsx and fru genes in D. melanogaster, mosquito and sand fly species. Green boxes represent non-sex-specific coding regions; azure boxes represent male-specific untranslated regions; pink boxes represent female-specific untranslated regions; blue and red boxes represent male-specific and female-specific coding regions, respectively; yellow vertical bars indicate the position of the putative TRA/TRA-2 binding sites; white vertical bars indicate the degenerated mosquito putative TRA/TRA-2 binding sites. b WebLogo consensus sequence of the putative TRA/TRA-2 binding sites of Brachycera and Nematocera species. Within sand flies, L. longipalpis exhibits the less conserved TRA/TRA-2 binding sites, as expected for a species with upstream regulator/s of the alternative splicing of dsx and fru genes different from tra