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Table 5 The top ten canonical pathways for Charolais steers within each dietary phase for which IPA was performed

From: The effect of breed and diet type on the global transcriptome of hepatic tissue in beef cattle divergent for feed efficiency

Diet-Breed Combination

Canoncial pathway

Differentially Expressed Genes

P-value

CH.H1

Toll-like Receptor Signalling

IL1A, JUN, MAP2K6 , NFKBIA, TNFAIP3, UBA52

8.71E-09

CD40 Signalling

IRS2, JUN, MAP2K6 , NFKBIA, TNFAIP3

0.00015

IL-6 Signalling

CSNK2B, IL1A, IRS, JUN, MAP2K6, NFKBIA

0.00017

Aryl Hydrocarbon Signalling

ALDH9A1, IL1A, JUN, MYC, TFDP1, TGM2

0.00028

Cholecystokinin/Gastrin mediated Signalling

IL1A, JUN, MAP2K6, MAPK7, RND3

0.00046

p53 Signalling

GADD45G, IRS2, JUN, TNFRSF10A, TP53INP1

0.00071

TNFR2 Signalling

JUN, NFKBIA, TNFAIP3

0.00093

Acute Phase Response Signalling

HP, IL1A, JUN, MAP2K6 , NFKBIA, SAA1

0.00097

IL-10 Signalling

IL1A, JUN, MAP2K6 , NFKBIA

0.001

NFKB Signalling

CSNK2B, IL1A, IRS2, MAP2K6 , NFKBIA, TNFAIP3

0.0013

CH.ZG

Glycine Betaine Degradation

BHMT2, DMGDH, SARDH

0.000029

Acute Phase Response Signalling

C5, FGG, HP, HRAS , LBP, SERPINA3

0.0009

Hereditary Breast Cancer Signalling

CCND1 , FGFR3 , GADD45G , HDAC5 , HRAS

0.0027

EIF2 Signalling

ATF5 , CCND1 , EIF1 , FGFR3 , FGFR3 , HRAS , RPL13

0.0033

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

C5, CCND1 , FGFR3 , HRAS , IL17RC , MIF , TRAF4

0.0043

Extrinsic Prothombin Activation Pathway

F5, FGG

0.0045

Chronic Myeloid Leukemia Signalling

CCND1 , FGFR3 , HDAC5 , HRAS

0.0056

Germ Cell-Sertoli Junction Signalling

BCAR1 , FGFR3 , HRAS , TUBA4A , TUBB4B

0.0057

Methylglyoxal Degradation VI

LDHD

0.0063

GADD45 Signalling

CCND1, GADD45G

0.0063

  1. H1 high concentrate, phase 1, ZG Zero-grazed grass, CH Charolais; P-value = Fisher’s exact test P-value, bold text indicates gene downregulation in low-RFI steers