The effect of breed and diet type on the global transcriptome of hepatic tissue in beef cattle divergent for feed efficiency

Table 6 The top ten canonical pathways for Holstein-Friesian steers offered the high-concentrate one diet

HF.H1	Glutathione-mediated Detoxification	ANPEP, *GSTA4* , *GSTM1*	4.92E-08
	2-amino-3-carboxymuconate Semialdehyde Degradation to Glutaryl-CoA	*ACMSD*	1.693E-05
	Branched-chain α-keto acid Dehydrogenase Complex	*DLD*	0.00016
	2-ketoglutarate Dehydrogenase Complex	*DLD*	0.00024
	2-oxobutanoate Degradation I	*DLD*	0.00024
	Glycine Cleavage Complex	*DLD*	0.00034
	Acetyl-CoA Biosynthesis I (Pyruvate Dehydrogenase Complex)	*DLD*	0.00045
	Fc Epsilon RI Signalling	FCER1A, RAC1	0.00052
	Phagosome Formation	FCER1A, RAC1	0.00069
	Aryl Hydrocarbon Receptor Signaling	*GSTM1, GSTA4*	0.00076

H1 high concentrate, phase 1, HF Holstein-Friesian; P-value = Fisher’s exact test P-value, bold text indicates gene downregulation in low-RFI steers

ISSN: 1471-2164