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Table 2 DEGs, DEPs and DEMs involved in the pathways

From: Integrated application of multi-omics provides insights into cold stress responses in pufferfish Takifugu fasciatus

Pathway Gene/Protein Metabolite
Pyrimidine metabolism Uridine phosphorylase 2 Uridine
Biosynthesis of unsaturated fatty acids Acyl-CoA desaturase Arachidonic acid (peroxide free) ;
(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Amino sugar and nucleotide sugar metabolism N-acetyl-D-glucosamine kinase D-mannose
Valine, leucine and isoleucine degradation Acetoacetyl-CoA synthetase# L-leucine
Glutathione metabolism Glutathione S-transferase omega-1 Glutathione disulfide
Lysosome Acid phosphatase D-mannose
ABC transporters Bile salt export pump;
Canalicular multispecific organic anion transporter 1+
Maltotriose;L-lysine;
L-leucine;D-mannose;
D-maltose;Betaine;
cAMP signaling pathway Hormone-sensitive lipase+ Adenosine
Vitamin digestion and absorption Retinol-binding protein 2 Pantothenate;
Nicotinamide;
Bile secretion Solute carrier family 2, facilitated glucose transporter member 1;
Ubiquitin-associated protein 1-like;
Bile salt export pump;
Canalicular multispecific organic anion transporter 1+
Taurocholate;
L-carnitine
Retrograde endocannabinoid signaling Guanine nucleotide-binding protein subunit beta-4 Arachidonic acid (peroxide free) ;
PC(16:0/16:0)
Serotonergic synapse Guanine nucleotide-binding protein subunit beta-4 Arachidonic acid (peroxide free) ;
Regulation of lipolysis in adipocyte Hormone-sensitive lipase+ Arachidonic acid (peroxide free) ;
Adenosine
Aldosterone synthesis and secretion Hormone-sensitive lipase+ Arachidonic acid (peroxide free) ;
Longevity regulating pathway – worm Acyl-CoA desaturase Nicotinamide
Central carbon metabolism in cancer Solute carrier family 2, facilitated glucose transporter member 1 L-leucine
Morphine addiction Guanine nucleotide-binding protein subunit beta-4 Adenosine
Alcoholism Guanine nucleotide-binding protein subunit beta-4 Adenosine
Parkinson disease ATP synthase-coupling factor 6 Adenosine
Insulin resistance Solute carrier family 2, facilitated glucose transporter member 1 Acetylcarnitine
  1. “↑” superscripts indicate significantly up-regulated
  2. “↓” superscripts indicate significantly down-regulated
  3. “+” superscript indicates that the gene was significantly up-regulated at the mRNA level and significantly down-regulated at the protein level
  4. “#” superscript indicates that the gene was significantly down-regulated at the mRNA level and significantly up-regulated at the protein level