Table 2 DEGs, DEPs and DEMs involved in the pathways
Pathway | Gene/Protein | Metabolite |
|---|---|---|
Pyrimidine metabolism | Uridine phosphorylase 2↑ | Uridine ↓ |
Biosynthesis of unsaturated fatty acids | Acyl-CoA desaturase↑ | Arachidonic acid (peroxide free) ↓; (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid↑ |
Amino sugar and nucleotide sugar metabolism | N-acetyl-D-glucosamine kinase ↓ | D-mannose↑ |
Valine, leucine and isoleucine degradation | Acetoacetyl-CoA synthetase# | L-leucine↑ |
Glutathione metabolism | Glutathione S-transferase omega-1↑ | Glutathione disulfide ↑ |
Lysosome | Acid phosphatase ↓ | D-mannose↑ |
ABC transporters | Bile salt export pump↑; Canalicular multispecific organic anion transporter 1+ | Maltotriose↑;L-lysine↑; L-leucine↑;D-mannose↑; D-maltose↑;Betaine↓; |
cAMP signaling pathway | Hormone-sensitive lipase+ | Adenosine↑ |
Vitamin digestion and absorption | Retinol-binding protein 2↑ | Pantothenate↑; Nicotinamide↑; |
Bile secretion | Solute carrier family 2, facilitated glucose transporter member 1↑; Ubiquitin-associated protein 1-like↑; Bile salt export pump↑; Canalicular multispecific organic anion transporter 1+ | Taurocholate↑; L-carnitine↑ |
Retrograde endocannabinoid signaling | Guanine nucleotide-binding protein subunit beta-4↓ | Arachidonic acid (peroxide free) ↓; PC(16:0/16:0) ↑ |
Serotonergic synapse | Guanine nucleotide-binding protein subunit beta-4↓ | Arachidonic acid (peroxide free) ↓; |
Regulation of lipolysis in adipocyte | Hormone-sensitive lipase+ | Arachidonic acid (peroxide free) ↓; Adenosine↑ |
Aldosterone synthesis and secretion | Hormone-sensitive lipase+ | Arachidonic acid (peroxide free) ↓; |
Longevity regulating pathway – worm | Acyl-CoA desaturase↑ | Nicotinamide↑ |
Central carbon metabolism in cancer | Solute carrier family 2, facilitated glucose transporter member 1↑ | L-leucine↑ |
Morphine addiction | Guanine nucleotide-binding protein subunit beta-4↓ | Adenosine↑ |
Alcoholism | Guanine nucleotide-binding protein subunit beta-4↓ | Adenosine↑ |
Parkinson disease | ATP synthase-coupling factor 6↑ | Adenosine↑ |
Insulin resistance | Solute carrier family 2, facilitated glucose transporter member 1↑ | Acetylcarnitine↑ |