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Fig. 4 | BMC Genomics

Fig. 4

From: Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers

Fig. 4

Epigenetic features in γH2AX binding regions. Average γH2AX binding relative to input was compared to the binding of indicated histone marks using published histone ChIP-seq data obtained from immortalized human B lymphocytes available in NCBI Gene Expression Omnibus. The dotted line indicates the center of the modified histone proteins, H3K27me3, H3K9me3, H3K9Ac and H3K4me3. X axis stands for these modified histone proteins distribution on the chromatin, and y-axis stands for the γH2AX binding signals corresponding to the four modified histone proteins position. γH2AX is enriched at H3K27me3 or H3K9me3 bound chromatin while depleted at H3K9Ac or H3K4me3 bound chromatin. Red dotted line indicates the center of the histone variant binding site

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