Table 10 Function enrichment analysis of the protein complexes identified by SE-DMTG and other algorithms on different datasets
| Â | Algorithms | PC | <E-15 | <E-10 | <E-5 | significant | Avg p-value |
|---|---|---|---|---|---|---|---|
Yeast | |||||||
Krogan core | DPClus | 497 | 37(7.44%) | 67(13.48%) | 186(37.42%) | 231(46.47%) | 1.12e-05 |
| Â | IPCA | 579 | 191(32.99%) | 268(46.29%) | 435(75.13%) | 487(84.11%) | 8.24e-06 |
| Â | CMC | 2136 | 13(0.61%) | 109(5.1%) | 559(26.17%) | 997(46.68%) | 2.36e-05 |
| Â | COACH | 348 | 87(25.0%) | 147(42.24%) | 253(72.7%) | 290(83.33%) | 1.04e-05 |
| Â | SPICi | 227 | 32(14.1%) | 54(23.79%) | 107(47.14%) | 121(53.31%) | 4.30e-06 |
| Â | ClusterONE | 243 | 40(16.46%) | 80(32.92%) | 153(62.96%) | 172(70.78%) | 7.54e-06 |
| Â | WPNCA | 374 | 140(37.43%) | 209(55.88%) | 311(83.15%) | 340(90.9%) | 5.00e-06 |
| Â | SE-DMTG | 371 | 87(23.45%) | 162(43.67%) | 295(79.52%) | 318(85.72%) | 4.47e-06 |
DIP | DPClus | 909 | 49(5.39%) | 92(10.12%) | 267(29.37%) | 353(38.83%) | 6.20e-05 |
| Â | IPCA | 1242 | 345(27.78%) | 583(46.94%) | 904(72.79%) | 1032(83.1%) | 1.16e-05 |
| Â | CMC | 1192 | 63(5.29%) | 149(12.5%) | 397(33.31%) | 553(46.4%) | 1.76e-05 |
| Â | COACH | 329 | 117(35.56%) | 184(55.92%) | 275(83.58%) | 295(89.66%) | 5.65e-06 |
| Â | SPICi | 402 | 37(9.2%) | 63(15.67%) | 144(35.82%) | 189(47.01%) | 1.73e-05 |
| Â | ClusterONE | 341 | 37(10.85%) | 72(21.11%) | 176(51.61%) | 201(58.94%) | 3.27e-05 |
| Â | WPNCA | 654 | 289(44.19%) | 420(64.22%) | 560(85.63%) | 605(92.51%) | 6.95e-06 |
| Â | SE-DMTG | 758 | 171(22.56%) | 293(38.65%) | 571(75.33%) | 633(83.51%) | 1.99e-05 |
combined6 | DPClus | 658 | 54(8.21%) | 96(14.59%) | 225(34.19%) | 275(41.79%) | 9.87e-06 |
| Â | IPCA | 2160 | 849(39.31%) | 1173(54.31%) | 1724(79.82%) | 1869(86.53%) | 4.15e-06 |
| Â | CMC | 892 | 71(7.96%) | 113(12.67%) | 300(33.63%) | 400(44.84%) | 1.63e-05 |
| Â | COACH | 682 | 186(27.27%) | 273(40.03%) | 440(64.52%) | 514(75.37%) | 9.79e-06 |
| Â | SPICi | 348 | 37(10.63%) | 69(19.83%) | 168(48.28%) | 203(58.34%) | 1.67e-05 |
| Â | ClusterONE | 648 | 57(8.8%) | 105(16.21%) | 245(37.81%) | 306(47.22%) | 1.31e-05 |
| Â | WPNCA | 898 | 441(49.11%) | 593(66.04%) | 751(83.63%) | 801(89.2%) | 3.66e-06 |
| Â | SE-DMTG | 490 | 154(31.43%) | 222(45.31%) | 404(82.45%) | 423(86.33%) | 3.65e-06 |
Human | |||||||
DIP | DPClus | 747 | 11(1.47%) | 30(4.01%) | 227(30.38%) | 336(44.97%) | 1.47e-05 |
| Â | IPCA | 904 | 11(1.22%) | 57(6.31%) | 359(39.72%) | 465(51.45%) | 9.76e-06 |
| Â | CMC | 358 | 16(4.47%) | 38(10.62%) | 169(47.21%) | 231(64.53%) | 1.64e-05 |
| Â | COACH | 389 | 15(3.86%) | 45(11.57%) | 236(60.67%) | 316(81.24%) | 1.51e-05 |
| Â | SPICi | 369 | 12(3.25%) | 32(8.67%) | 127(34.42%) | 191(51.76%) | 1.52e-05 |
| Â | ClusterONE | 363 | 14(3.86%) | 36(9.92%) | 151(41.6%) | 200(55.1%) | 1.08e-05 |
| Â | WPNCA | 535 | 42(7.85%) | 114(21.31%) | 341(63.74%) | 424(79.25%) | 1.03e-05 |
| Â | SE-DMTG | 604 | 38(6.29%) | 91(15.06%) | 322(53.31%) | 413(68.38%) | 1.40e-05 |
HPRD+BioGRID | DPClus | 1881 | 126(6.7%) | 240(12.76%) | 692(36.79%) | 960(51.04%) | 1.60e-05 |
| Â | IPCA | 9989 | 1605(16.07%) | 3566(35.7%) | 6929(69.37%) | 7615(76.24%) | 5.06e-06 |
| Â | CMC | N/A | N/A | N/A | N/A | N/A | N/A |
| Â | COACH | 4296 | 1106(25.74%) | 1855(43.17%) | 3218(74.9%) | 3596(83.7%) | 7.50e-06 |
| Â | SPICi | 1100 | 84(7.64%) | 152(13.82%) | 374(34.0%) | 522(47.45%) | 1.65e-05 |
| Â | ClusterONE | 1763 | 123(6.98%) | 227(12.88%) | 531(30.12%) | 695(39.42%) | 1.21e-05 |
| Â | WPNCA | 2750 | 719(26.15%) | 1126(40.95%) | 1867(67.9%) | 2164(78.7%) | 1.00e-05 |
| Â | SE-DMTG | 2773 | 626(22.57%) | 1059(38.18%) | 1935(69.77%) | 2235(80.59%) | 1.15e-05 |
Mouse | |||||||
BioGRID | DPClus | 669 | 7(1.05%) | 29(4.34%) | 182(27.21%) | 304(45.45%) | 2.67e-05 |
| Â | IPCA | 1888 | 121(6.41%) | 427(22.62%) | 767(40.63%) | 1069(56.63%) | 1.47e-05 |
| Â | CMC | 737 | 4(0.54%) | 30(4.07%) | 217(29.44%) | 367(49.79%) | 2.19e-05 |
| Â | COACH | 611 | 59(9.66%) | 112(18.33%) | 313(51.23%) | 430(70.38%) | 1.64e-05 |
| Â | SPICi | 288 | 1(0.35%) | 18(6.25%) | 101(35.07%) | 145(50.35%) | 1.91e-05 |
| Â | ClusterONE | 327 | 3(0.92%) | 27(8.26%) | 121(37.01%) | 177(54.14%) | 2.42e-05 |
| Â | WPNCA | 828 | 170(20.53%) | 275(33.21%) | 525(63.4%) | 657(79.34%) | 1.23e-05 |
| Â | SE-DMTG | 832 | 60(7.21%) | 140(16.83%) | 401(48.2%) | 519(62.38%) | 2.13e-05 |