Table 2 Tissue and system specificity of histone deacetylases. Reported data is from cited references [5, 17, 45,46,47]. Predicted data is based on enrichment of TFBS trimers in the analysis described in the main text. Following TF groupings in Genomatix, non-exclusive refers to the presence of TFs that are active in most tissues, and preferential refers to TFs that are more highly expressed in these systems than in others. Dark bullet points denote predicted activity, outline bullet points denote a predicted lack of activity in these systems
From: Promoter conservation in HDACs points to functional implications
| Â | Â | Reported tissue specificity | Predicted non-exclusive system specificity | Predicted preferential system specificity |
|---|---|---|---|---|
Class I | HDAC1 | Ubiquitous | All | All |
HDAC2 | Ubiquitous | All Except o Respiratory | • Cardiovascular/Hematopoietic • Embryo • Endocrine • Immune/Lymphatic • Muscular • Nervous | |
HDAC3 | Ubiquitous | All Except o Integumentary o Respiratory | • Cardiovascular/Hematopoietic • Immune/Lymphatic • Muscular | |
HDAC8 | • Muscular (smooth muscle) | All | All | |
Class IIA | HDAC4 | • Cardiovascular/Hematopoietic • Muscular (smooth muscle) • Nervous (brain) • Endocrine (liver) | All | All Except o Respiratory |
HDAC5 | • Cardiovascular/Hematopoietic • Muscular (smooth muscle) • Nervous (brain) • Endocrine (liver) | All Except o Respiratory | All Except o Integumentary o Respiratory o Skeletal | |
HDAC7 | • Cardiovascular/Hematopoietic • Muscular (smooth muscle) • Endocrine (several tissues) • Skeletal | • Cardiovascular/Hematopoietic • Digestive • Endocrine • Excretory • Immune/Lymphatic • Muscle • Nervous | • Cardiovascular/Hematopoietic • Digestive • Endocrine • Excretory • Muscle • Nervous | |
HDAC9 | • Immune/Lymphatic • Muscular (smooth muscle) • Nervous (brain) | All Except o Digestive o Excretory o Integumentary o Respiratory | • Cardiovascular/Hematopoietic • Embryo • Immune/Lymphatic • Muscular | |
Class IIB | HDAC6 | • Cardiovascular/Hematopoietic • Endocrine (liver, pancreas) • Nervous (brain) | All Except o Respiratory | All Except o Embryo o Respiratory |
HDAC10 | • Endocrine (kidney, liver, spleen) • Excretory (kidney) | All Except o Integumentary o Respiratory o Skeletal | • Cardiovascular/Hematopoietic • Endocrine • Immune/Lymphatic • Muscular | |
Class IV | HDAC11 | • Cardiovascular/Hematopoietic • Endocrine (kidney) • Excretory (kidney) • Muscular (smooth muscle) • Nervous (brain) | • Cardiovascular/Hematopoietic • Digestive • Endocrine • Excretory • Embryo • Immune/Lymphatic • Nervous • Reproductive | Not enough TF trimers for a signal |