Fig. 4

Phylogenetic tree constructed based on the core genes of Enterococcus (E.) faecium isolates. The phylogenetic tree was constructed using the DNA sequences of 871 core genes of 161 isolates of E. faecium and 3 isolates of E. mundti. Enterococcus mundtii is the closest phylogenetic relative of E. faecium and was thus included as outgroup. The color of the isolate name represents the origin of the isolate. Isolates labeled with star, dot, and triangle in the out circle were clustered in clade A1 (hospital-associated), clade A2 (animal-associated), and clade B (commensal-associated), respectively, in Lebreton et al. [9]. The number of antibiotic resistance genes was labeled in the out circle