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Table 3 Main overrepresented biological processes shared by genes selected as predictors of feed efficiency traits

From: Investigation of muscle transcriptomes using gradient boosting machine learning identifies molecular predictors of feed efficiency in growing pigs

GO terms

Nb genes

E

P Value

Clustered genes

RFI (clustered pathways among 222 VIP)

 GO:0051270~regulation of cell motion

12

3.35

< 0.001

BCL2, F10, HBZGF, HDAC5, INS-IGF2, LAMA4, NTN1, NRP1, PIK3R1,

PDGFRB, SERPINE2, TGFR3

 GO:0007167~enzyme linked receptor protein signaling pathway

14

2.36

< 0.001

AMHR2, NRP1, INS-IGF2, TIPARP, TRIO, GRB10, UTP11L, PDGFRB, SPTBN1, HBEGF, ROR2, TGFBR3, ANGPTL1, PIK3R1

 GO:0001558~regulation of cell growth

8

1.86

0.008

NRP1, CD44, INS-IGF2, ABTB2, BCL2, HBEGF, NTN1, MAP 2 K5

 GO:0009725~response to hormone stimulus

12

1.81

0.004

HDAC5, PLA2G4A, AR, GRB10, CCND2, INS-IGF2, BCL2, NCOA6, TGFBR3, MGP, CA2, PIK3R1

 GO:0019318~hexose metabolic process

8

1.79

0.008

PDK1, TPI1, PHKB, INS-IGF2, UGDH, FUT2, SLC35A2, PMM1

 GO:0007517~muscle organ development

8

1.79

0.01

SRPK3, GATA6, TIPARP, PDGFRB, TGFBR3, HBEGF, ZFPM2, CBY1

 GO:0032844~regulation of homeostatic process

5

1.38

0.05

PLA2G4A, CD44, BCL2, RYR2, CA2

 GO:0060284~regulation of cell development

10

1.33

< 0.001

HDAC5, NRP1, PSEN1, CCND2, INS-IGF2, BCL2, HOXD3, RTN4R, TGFBR3, NTN1

 GO:0048705~skeletal system morphogenesis

7

1.31

0.004

TULP3, PSEN1, HOXD3, TIPARP, PDGFRB, ROR2, MGP

 GO:0006468~protein amino acid phosphorylation

15

1.30

0.03

SRPK3, PDK1, AMHR2, TWF1, TRIO, ADRBK1, CDKL2, PSEN1, BCL2, SPTBN1, ROR2, PDGFRB, TGFBR3, MERTK, MAP 2 K5

 GO:0010035~response to inorganic substance

9

1.24

0.003

ACTB, PLA2G4A, SLC1A3, BCL2, UROS, RYR2, MGP, ADRBK1, CA2

 GO:0006954~inflammatory response

8

1.20

0.08

HDAC5, CD44, INS-IGF2, FCN2, TICAM2, PSEN1, NLRP3, NFX1

 GO:0031667~response to nutrient levels

8

1.10

0.08

PLA2G4A, PSEN1, CD44, BCL2, RYR2, MGP

 GO:0006650~glycerophospholipid metabolic process

5

1.08

0.08

PLA2G4A, ABHD5, ADNP, LPCAT2, PIK3R1

 GO:0016053~organic acid biosynthetic process

6

1.08

0.04

TPI1, SLC1A3, SCD, ABHD5, UROS, UGDH

FCR (clustered pathways among 267 VIP)

 GO:0007010~cytoskeleton organization

13

2.4

0.001

RND3, ACTC1, EZR, MACF1, CALD1, BCL2, SSH2, KRT8, ABI2, CNN1, TTN, PRKG1, EPB49

 GO:0007155~cell adhesion

20

1.85

0.011

TECTA, NRP1, OLR1, GMDS, LGALS4, CNKSR3, NLGN3, CLDN10, CLDN11, CD84, RND3, LAMA4,

EZR, ROBO1, COL27A1, BCL2, ACAN, MSN, PDZD2, EDA

 GO:0060284~regulation of cell development

8

1.78

0.038

NRP1, LYN, ROBO1, INS-IGF2, BCL2, HOXD3, SMAD3, IGF2, NTN1

 GO:0006006~glucose metabolic process

7

1.66

0.03

TPI1, PYGM, PHKB, PYGL, INS-IGF2, SDS, UGDH, IGF2

 GO:0060537~muscle tissue development

8

1.66

0.003

MYF6, ACTC1, GATA6, TIPARP, TTN, CHRNA1, HOMER1, PTEN

 GO:0005977~glycogen metabolic process

3

1.61

0.099

PYGM, PHKB, PYGL

 GO:0000902~cell morphogenesis

10

1.50

0.095

EZR, NRP1, SEMA6C, MACF1, ROBO1, BCL2, LIFR, SOX6, NTN1, MYCBP2

 GO:0001568~blood vessel development

9

1.42

0.034

CCM2, LAMA4, NRP1, ROBO1, TIPARP, TGFA, DBH, FIGF, PTEN

 GO:0045321~leukocyte activation

8

1.35

0.077

LYN, INS-IGF2, FYN, BCL2, SMAD3, MALT1, IGF2, HSPD1, ZNF3

 GO:0001501~skeletal system development

10

1.29

0.055

GNAQ, INS-IGF2, GFPT1, BCL2, HOXD3, TIPARP, ACAN, SMAD3, GNAS, IGF2, SOX6

 GO:0016052~carbohydrate catabolic process

6

1.27

0.025

GPD1L, OVGP1, TPI1, PYGM, PYGL, FUT1

 GO:0030163~protein catabolic process

15

1.19

0.093

FEM1C, SOCS3, WWP1, USP9X, SOCS6, HECTD2, MALT1, ASB13,

SMURF1, UBE2J2, SPOPL, UBE2Q1, USP32, MYCBP2, RNF111

FCR (clustered pathways among 218 VIP)

 GO:0051270~regulation of cell motion

15

1.95

0.001

RET, MSH2, MDGA1, ARID5B, NR4A2, KDR, DSTN, IGSF8, MACF1, FYN, BAX, PAK4, FOXE1, THBS1, ACVR1

 GO:0034613~cellular protein localization

13

1.58

0.004

COPA, CLTA, YWHAZ, LTBP2, AP1G1, AKAP12, PTPRU, SYNGR1, MACF1, RPL23, BAX, CHM, RAB11A

 GO:0006163~purine nucleotide metabolic process

7

1.54

0.02

ATP1B1, ENPP1, MSH2, ATP1B4, RAB11A, ACLY, MYH7

 GO:0001568~blood vessel development

9

1.49

0.009

EPAS1, BAX, CHM, ZFPM2, TNNI3, THBS1, MMP2, KDR, ACVR1

 GO:0006732~coenzyme metabolic process

6

1.25

0.04

DLD, ACLY, ALDH1L2, GCLM, MTHFD1L, MOCS1

 GO:0042592~homeostatic process

17

1.22

0.02

ENPP1, EPAS1, PTH1R, PRDX3, TNNI3, GCLM, MBP, KDR, RPS19, SLC4A11, RHCG, IL20RB, BAX, DLD, FABP4, IKBKB, CLN6

 GO:0003006~reproductive developmental process

8

1.10

0.04

HSPA2, MSH2, BAX, DLD, SF1, DHCR24, KDR, ACVR1

 GO:0048514~blood vessel morphogenesis

7

1.08

0.04

EPAS1, BAX, ZFPM2, TNNI3, THBS1, KDR, ACVR1

 GO:0043066~negative regulation of apoptosis

11

1.04

0.01

YWHAZ, MSH2, BAX, BTC, NR4A2, PRDX3, IKBKB, THBS1, GCLM, DHCR24, ACVR1

  1. Very important genes (VIP) for prediction of feed efficiency traits (RFI: residual feed intake; FCR: feed conversion ratio; FCRe: net energy based-feed conversion ratio). Genes were clustered into functional groups using DAVID tool. The enrichment score (E > 1) for each cluster and P-value of the enrichment for the corresponding Gene Ontology (GO) terms are provided. Expression levels of genes indicated in bold font were further measured by qPCR