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Table 8 Comparison to other cathelicidins

From: The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters

Name

Species

Sequence

Length

VK-CATH4.1/ VK-CATH4.2 Similarity (%)

VK-CATH4.1

V. komodoensis

----FRWRRFFRKAKRFLKRHGVSIAIGTVRLLRRFG-

33

100/70.00

VK-CATH4.2

V. komodoensis

----RRWRRFFQKAKRFVKRHGVSIAVGAYRIIG----

30

70.00/100.00

Reptiles (Squamates)

 GJ-CATH

G. japonicus

-----RWRRFWGKAKRGIKKHGVSIALAALRLRG----

29

62.07/65.52

 AC-CATH

A. carolinensis

-----RWGRFWRGAKRFVKKHGVSIALAGLR-------

26

65.38/65.38

 PB-CATH

P. bivitatis

-----RWRRFIRGAGRFARRYGWRIALG----------

23

60.87/56.52

 NA-CATH

N. atra

----KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF

34

21.21/26.67

Other Vertebrates

 AM-CATH

A. mississippiensis

-KIKKGFKKIFKRLPP--IGVGVSIPLAGKR-------

28

24.00/24.00

 CAP18

O. cuniculus

-GLRKRLRKFRNKIKEKLKKIGQKIQGFVPKLAPRTDY

37

33.33/26.67

 SMAP-29

O. aries

----RGLRRLGRKIAHGVKKYGPTVL-RIIRIAG----

29

24.14/34.48

 cc-CATH

C. coturnix

LVQRGRFGRFLKKVRRFIPKVIIAAQIG-----SRFG

32

39.29/28.00

 CMAP27

G. gallus

-----RFGRFLRKIRRFRPKVTITIQGS-----ARFG-

27

40.74/29.17

 Lactoferritin

B. taurus

-FKCRRWQWR-------MKKLGAPSITCV---RRAF--

25

27.27/25.00

  1. Homology and alignment of proposed Komodo dragon cathelicidin peptides with known peptides in the Antimicrobial Peptide Database APD3 [64]. These sequence alignments and sequence similarities were generated using Clustal ω [68]