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Table 7 Characterization of the seven predicted deleterious SNPs annotated in PCGs for internal organ traits in chickens

From: Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens

Gene Symbol

SNP ID

GGA

Position1

Amino acid change

SIFT score2

TNFSF11

rs312442403

1

166,510,185

Arg/Gln

Deleterious low confidence3 (0.03)

NR4A2

g.36224286 > C/T

7

36,224,286

Val/Met

Deleterious (0)

g.36225242 > G/T

36,225,242

Arg/Ser

Deleterious (0)

g.36225278 > C/T

36,225,278

Val/Met

Deleterious (0.01)

ITGB4

rs313279811

18

4,785,491

His/Tyr

Deleterious (0.01)

rs316340790

4,787,392

Asp/Asn

Deleterious (0.04)

rs732847450

4,790,177

Met/Ile

Deleterious (0.03)

  1. 1Position based on Gallus_gallus 5.0 assembly
  2. 2SIFT (Sorting Intolerant From Tolerant) score
  3. 3Deleterious low confidence: little sequence diversity in this position affecting the substitution model, and consequently the averages of conservation value [35]