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Table 2 Summary of gene modules identified with weighted correlation network analysis (WGCNA). Only showing modules with significant correlation with the treatments. Network/module is number of genes found by STRING analysis out of the whole set of module genes that passed the selection threshold (ModuleMembership > 0.8 and treatment p-value > 0.05). Top hub genes were chosen based on high modular membership (kME) value and highest degree in PPI network

From: Exploration of tissue-specific gene expression patterns underlying timing of breeding in contrasting temperature environments in a song bird

Tissue

Module color

Number of genes

Most significant correlation

Network/module

Hub gene symbol

Gene name

Hypothalamus

 

Brown

1668

Time point

117/130

ADCY2

adenylate cyclase 2

 

Turquoise

5631

Time point

395/493

HSPA8

heat shock protein family A (Hsp70) member 8

 

Blue

5068

Time point

784/911

MAPK1

mitogen-activated protein kinase 1

 

Green

1022

Time point

65/72

EPRS

glutamyl-prolyl-tRNA synthetase

 

Yellow

1031

Line

55/58

  

Liver

 

Pink

714

Temperature

41/49

  
 

Turquoise

3149

Time point

202/264

GART

phosphoribosylglycinamide formyltransferase…

 

Magenta

537

Time point

30/31

SNAP25

synaptosomal-associated protein 25

 

Red

901

Time point

32/39

  
 

Green

951

Time point

39/46

HSPA4

heat shock protein family A (Hsp70) member 4

 

Blue

3115

Time point

263/289

PTPRC

protein tyrosine phosphatase, receptor type C

 

Purple

434

Time point

21/25

  
 

Salmon

363

Line

25/34

POLR3B

RNA polymerase III subunit B

 

Midnightblue

160

Line

6/13

  

Ovary

 

Yellow

2229

Time point

147/174

HSP90AA1

heat shock protein 90 alpha family class A member 1

 

Turquoise

6579

Time point

913/1372

ACLY

ATP citrate lyase

 

Blue

5573

Time point

1722/2252

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

 

Brown

3093

Time point

557/658

AKT1

AKT serine/threonine kinase 1

 

Cyan

123

Line

5/15

  
 

Midnightblue

102

Line

3/3

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