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Table 2 Summary of gene modules identified with weighted correlation network analysis (WGCNA). Only showing modules with significant correlation with the treatments. Network/module is number of genes found by STRING analysis out of the whole set of module genes that passed the selection threshold (ModuleMembership > 0.8 and treatment p-value > 0.05). Top hub genes were chosen based on high modular membership (kME) value and highest degree in PPI network

From: Exploration of tissue-specific gene expression patterns underlying timing of breeding in contrasting temperature environments in a song bird

Tissue Module color Number of genes Most significant correlation Network/module Hub gene symbol Gene name
Hypothalamus
  Brown 1668 Time point 117/130 ADCY2 adenylate cyclase 2
  Turquoise 5631 Time point 395/493 HSPA8 heat shock protein family A (Hsp70) member 8
  Blue 5068 Time point 784/911 MAPK1 mitogen-activated protein kinase 1
  Green 1022 Time point 65/72 EPRS glutamyl-prolyl-tRNA synthetase
  Yellow 1031 Line 55/58   
Liver
  Pink 714 Temperature 41/49   
  Turquoise 3149 Time point 202/264 GART phosphoribosylglycinamide formyltransferase…
  Magenta 537 Time point 30/31 SNAP25 synaptosomal-associated protein 25
  Red 901 Time point 32/39   
  Green 951 Time point 39/46 HSPA4 heat shock protein family A (Hsp70) member 4
  Blue 3115 Time point 263/289 PTPRC protein tyrosine phosphatase, receptor type C
  Purple 434 Time point 21/25   
  Salmon 363 Line 25/34 POLR3B RNA polymerase III subunit B
  Midnightblue 160 Line 6/13   
Ovary
  Yellow 2229 Time point 147/174 HSP90AA1 heat shock protein 90 alpha family class A member 1
  Turquoise 6579 Time point 913/1372 ACLY ATP citrate lyase
  Blue 5573 Time point 1722/2252 SRC SRC proto-oncogene, non-receptor tyrosine kinase
  Brown 3093 Time point 557/658 AKT1 AKT serine/threonine kinase 1
  Cyan 123 Line 5/15   
  Midnightblue 102 Line 3/3