Fig. 7

DMR genes in specific hypothalamus cell-types. a: Distribution of DMR genes (rows) across GABAergic and glutamatergic neuron subtypes in the hypothalamus (columns) from [57]. Blue cells indicate presence of a gene in a cell type, and pink shading behind gene names indicates transcription factor genes. Starting from the bottom, rows represent DMR genes that were found in progressively more cell types. Most genes were in one type, 11 genes were in 2 types, and 4 genes were in more than 2 types, as demarcated by the solid black horizontal lines. Dashed horizontal lines are for visual reference. Starting from the left, the first 15 columns represent GABAergic clusters sorted by the number of DMR genes they contained, then the final 9 columns (right of solid black vertical line) represent glutamatergic clusters. Note that not all clusters from [57] contained a DMR gene. GABA8 and GABA9 represent cells in the suprachiasmatic nucleus (SCN, dark grey shading), while GABA11, GABA12, GABA15, Glu11, and Glu13 represent arcuate nucleus cells (ARH, light grey shading), and GABA11 and Glu10 represent GnRH neurons (bold and underlined). Blue, yellow, and green bars below columns match the colors in the venn diagram in c.b: DMR genes in GABAergic cell clusters across GO categories that were enriched specifically in these genes (Benjamini-Hochberg-adjusted p < 0.1): Generation of neurons (GO:0048699), Neuron projection (GO:0043005), Transcriptional regulation (GO:0006355). Black box groups genes that are part of voltage-gated potassium channel complexes. c: Venn diagram of some DMR genes that were in the stage 1 and/or stage 2 oligodendrocyte progenitor cell (OPC) coexpression clusters from [57]. See Additional file 2: Table S6 for all DMR genes in these clusters. Genes are shown from GO categories that were enriched specifically in OPC cluster DMR genes (Additional file 2: Table S8). Bold and italicized text indicate genes specific to the stage 2 or stage 1 clusters, respectively. The solid black box surrounds genes involved in cell adhesion, the dashed box surrounds genes involved in axonogenesis and/or neuron projection extension, and the shaded box surrounds transcription factor genes