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Fig. 2 | BMC Genomics

Fig. 2

From: Mitochondrial genomic variation drives differential nuclear gene expression in discrete regions of Drosophila gene and protein interaction networks

Fig. 2

Physical location and ID overlap between the sexes of DE genes in the DGRP-315 nuclear background. Physical chromosome locations are shown on the abscissa of the Manhattan plots (a, b, d, e, g, h) and the significance (−log10 p-value) is shown on the ordinal scale. Each datum represents an individual transcript. Female ΔmtDNA ‘haplotype’, ΔmtDNA ‘species’, and G x G ‘broadscale epistasis’ distributions are shown in a, d and g, respectively. Male ΔmtDNA ‘haplotype’, ΔmtDNA ‘species’, and G x G ‘broadscale epistasis’ distributions are shown in b, e, and h, respectively. Between-sex Venn intersections of DE genes (FDR < 0.05) and shown for ΔmtDNA ‘haplotype’, ΔmtDNA ‘species’, and G x G ‘broadscale epistasis’ in c, f, and i, respectively. Broadscale epistasis represents the totality of interactions between the complete nuclear genomes and the complete mtDNA genomes. In other words, these are not specific SNP interactions, but whole scale genome interactions. Broadscale mitonuclear interaction genes are estimated as the (Zim53-sm21) mtDNA contrast in the DGRP-315 background contrasted against the (Zim53-sm21) contrast in the DGRP-820 background

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