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Fig. 5 | BMC Genomics

Fig. 5

From: Mitochondrial genomic variation drives differential nuclear gene expression in discrete regions of Drosophila gene and protein interaction networks

Fig. 5

Female-male enriched gene overlap and transcription factor binding site enrichments. The 200 top ranked genes in both males and females were intersected for the SAFE (a) and neighborhood enrichment analyses (b). The overlapping proteins were analyzed for transcription factor binding site enrichment using oPOSSUM-v3 [53]. The SAFE analysis overlap (34 genes (a and c)) and the network neighborhood score overlap (77 genes (b and d)) were both highly enriched for the giant (gt) TFBS motif. Z-scores represent over-representation of the TFBS motif relative to a background set. The dashed horizontal lines in d and e represent the mean z-score + 2*SD

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BMC Genomics

ISSN: 1471-2164

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