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Table 1 Top 5 GO terms overrepresented in DEGs in which upregulation during T. gondii infection was affected by CCR5-deficiency. To explore the functions of DEGs in which upregulation during infection was affected by CCR5-deficiency, GO term enrichment analysis was performed

From: Transcriptome analysis of the effect of C-C chemokine receptor 5 deficiency on cell response to Toxoplasma gondii in brain cells

Cell type

Accession no.

FDR

# DEGs

# reference genes

GO term

Astrocyte

GO:0006952

8.1E-24

49

1416

defense response

 

GO:0002376

5.7E-22

58

2282

immune system process

 

GO:0006955

2.5E-21

45

1297

immune response

 

GO:0051707

1.7E-18

34

879

response to other organism

 

GO:0043207

1.7E-18

34

881

response to external biotic stimulus

Microglia

GO:0001819

4.8E-06

15

401

positive regulation of cytokine production

 

GO:0002237

6.2E-05

12

359

response to molecule of bacterial origin

 

GO:0006954

6.4E-05

16

646

inflammatory response

 

GO:0001816

6.4E-05

17

704

cytokine production

 

GO:0001817

6.9E-05

16

632

regulation of cytokine production