Skip to main content

Table 2 The performance of our signature for pSCC and pADC samples in test datasets

From: A qualitative transcriptional signature for the histological reclassification of lung squamous cell carcinomas and adenocarcinomas

 

Data Source

pADC

pSCC

A- Sen

(rate)

A- Spe

(rate)

A- Acc

(rate)

Re (SCC) (rate)

Re (ADC) (rate)

“Golden”standard data

GSE19188

45

27

93.33%

96.30%

94.44%

3 (6.67%)

1 (3.70%)

E-MTAB-2435

0

63

98.41%

98.41%

1 (1.59%)

Total

45

90

93.33%

97.78%

96.30%

3 (6.67%)

2 (2.22%)

Integrated data (frozen)

GSE42127

90

32

90.00%

84.38%

88.52%

9 (10.00%)

5 (15.62%)

GSE50081

127

43

88.19%

86.05%

87.65%

15 (11.81%)

6 (13.95%)

GSE37745

40

24

95.00%

87.50%

92.19%

2 (5.00%)

3 (12.50%)

GSE31210

204

0

99.02%

99.02%

2 (0.98%)

GSE31546

13

0

100%

100%

0 (0.00%)

GSE14814

32

26

93.75%

96.15%

94.83%

2 (6.25%)

1 (3.85%)

GSE68465

299

0

98.66%

98.66%

4 (1.34%)

Total

805

125

95.78%

88.00%

94.73%

34 (4.22%)

15 (12.00%)

FFPE

GSE44170

0

38

92.11%

92.11%

3 (7.89%)

Mixed

TCGA

498

499

97.59%

83.57%

90.75%

12 (2.41%)

82 (16.43%)

Biopsy

GSE58661

42

36

95.24%

88.89%

92.31%

2 (4.76%)

4 (11.11%)

Poorly differentiated

GSE94601

19a

4a

100%

50.00%

91.30%

0 (0.00%)

2 (50.00%)

Total

1364

702

96.48%

84.90%

92.55%

48 (3.52%)

106 (15.10%)

  1. A-Sen represents the apparent sensibility, A-Spe represents the apparent specificity and A-acc represents the apparent accuracy
  2. Re (SCC) represents the number of pADC samples reclassified as SCC by signature
  3. Re (ADC) represents the number of pSCC samples reclassified as ADC by signature
  4. athe 19 pADCs and 4 pSCCs samples are poorly differentiated which were improperly assigned to LCC subtype before and reclassified by the authors using ADC and SCC immunomarkers