From: Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species
Name in article | Database name (feature) | Normalized name | Sp. | Experiment | Tissue/Cell type | Action | Ref. |
---|---|---|---|---|---|---|---|
ANRIL | CDKN2B-AS1 (h: 28tr; 3837 bp; 19ex) | ANRIL | h | Co-effects (6 yr-adiposity) | Umbilical cord | ↗lnc & ↗fat mass | [40] |
APOA1-AS | APOA1-AS (h: 2tr; 956 bp; 3ex) | APOA1-AS | h | KD (lnc) | HepG2 | ↗APO gene cluster: APOA1, APOC3, APOA4 | [41] |
APOA4-AS | Gm10680 (m: 1tr; 702 bp; 2ex) | APOA4-ASa | m | KD (lnc) | Liver | ↘APOA4 & ↘TG, Chol. | [42] |
FLRL5 | m | Co-effects (NAFLD) | Liver | ↗lnc, FADS2, ↘FABP5, LPL, ACMSD, | [43] | ||
AT102202 | – | HMGCR | h | KD (lnc) | HepG2 | ↗HMGCR | [39] |
AT115872 | SOD2-OT1 (h: 1tr; 1718 bp; 2ex) | SOD2-OT1a | h | KD (lnc) | HepG2 | ↘HMGCR | [39] |
Blnc1 | – | Blnc1a | m | Ov. (lnc) | Primary hepatocytes | ↗SREBP1c, FASN, SCD, DGAT2, FABP4, ABCA1, ABCG5, LPCAT3 | [44] |
CASIMO1 | SMIM22b | SMIM22a | h | Ov. (lnc) | MCF-7 | ↗Lipid droplet formation | [45] |
CRNDE | CRNDE (h: 24tr; 6325 bp; 2ex) | CRNDE | h | KD (lnc) | HCT116, HT29 | ↘FASN, DGKA, CDS1, PLCB3, PLCG1, ↗ACADVL, ACOT9, PI4KB | [46] |
ORat7 | c | Co-effects (Se-deficient diet) | Vein | ↗lnc, ↘ACADS | [47] | ||
E330013P06 | Carmn (m: 2tr; 1778 bp; 3ex) | CARMN | m | Ov. (lnc) | RAW 264.7 | ↗lipid uptake | [48] |
FLRL3 | Gm11832 (m: 1tr; 432 bp; 3ex) | RAD54B-AS1a | m | Co-effects (NAFLD) | Liver | ↗lnc, FADS2, ↘FABP5, LPL, ACMSD, | [43] |
FLRL8 | 1700067K01Rikb | -a | m | Co-effects (NAFLD) | Liver | ↗lnc, FADS2, ↘FABP5, LPL, ACMSD, | [43] |
Gm16551 | Gm16551 (m: 5tr; 3162 bp; 3ex) | LINCxxxxa | m | KD (lnc) | Liver | ↗ACLY, FASN, SCD & ↗TG | [49] |
H19 | H19 (m: 7tr; 2286 bp; 5ex) | H19 | m | Co-effects (FA) | Liver | ↗lnc, PTBP1 | [50] |
HAGLR | HAGLR (h: 17tr; 4095; 3ex) | HAGLRa | h | KD (lnc) | NSCLC cells | ↘FASN & ↘FA | [51] |
HOTAIR | HOTAIR (h: 5tr; 2421 bp; 7ex) | HOTAIRa | h | KD (lnc) | CNE2, 5-8F | ↘FASN & ↘FA | [52] |
HOXC-AS1 | HOXC-AS1 (h: 2tr; 548 bp; 2ex) | HOXC-AS1a | h | Ov. (lnc) | THP-1 | ↗HOXC6 & ↘Chol. | [53] |
HULC | – | HULC | h | Co-effects (HCC) | HepG2 | ↗lnc, ACSL1, PPARA & ↗TG, Chol. | [54] |
LeXis | 4930412L05Rik (m: 2tr; 1241 bp; 8ex) | LeXis | m | KO, KD, Ov. (lnc) | Liver | ↘CYP51A1, FDPS, MVK, MVD, SQLE, IDI1, LSS, PMVK & ↘Chol. | [55] |
LINC01138 | LINC01138 (h: 14tr; 2212 bp; 4ex) | LINC01138a | h | KD, Ov. (lnc) | Renal cell carcinoma | ↗SREBP1 activity & ↗lipid desaturation | [56] |
linc-ADAL | LINCADL (h: 1tr; 521 bp; 2ex) | LINCADLa | h | KD (lnc) | ASC | ↘PPARG, CEBPA, SREBF1, FASN, ELOVL6, ATGL & ↘TG | [57] |
lincRNA-DYNLRB2–2 | LINC01228 (h:1tr; 623 bp; 2ex) | LINC01228 | h | Co-effects (Ox-LDL) | THP-1 | ↗lnc, GPR119, ABCA1 & ↘Chol., ↗Efflux | [58] |
LINK-A | LINC01139 (h: 7tr; 1579; 2ex) | LINK-Aa | h | Co-effects (lipid-binding) | TNBC | ↗lnc with highest lipid enrichment | [59] |
LISPR1 | – | S1PR1-DTa | h | KD (lnc) | HUVEC | ↗S1PR1 | [60] |
lnc_DHCR24 | DHCR24-DT (h: 4tr; 440 bp; 2ex)c | DHCR24-DTa | c | Co-effects (fat line) | Liver | ↗lnc, DHCR24 | [20] |
lnc18q22.2 | LIVAR (h: 1tr; 384 bp; 2ex) | LIVAR | h | Co-effects (NASH) | Liver | ↗lnc, anti-apoptotic genes | [61] |
lncACACA | – | LINCxxxxa | h | Co-effects (LXR agonist) | THP-1 | ↗lnc | [62] |
lncARSR | LNCARSR d (h: 10tr; 2932 bp;2ex) | lncARSRa | m | Ov. (lnc) | Liver | ↗SREBP1c, FASN, ACC1, SCD, ↘CPT1A | [63] |
m | Ov. (lnc) | Liver | ↗HMGCR, HMGCS, SQLE, ↘CYP7A1 & ↗Chol. | [64] | |||
lncFASN | LINC01970 (h: 1tr; 1810 bp; 2ex) | LINC01970a | h | Co-effects (LXR agonist) | THP-1 | ↗lnc | [62] |
lnc-HC | – | lnc-HC | r | KD, Ov. (lnc) | Liver, CBRH-7919 | ↘CYP7A1, ABCA1 & ↘TG, Chol. | [65] |
lncHR1 | AC023161.1 d (h: 1tr; 420 bp; 2ex) | lncHR1 | m | Ov. (lnc) | Liver | ↘SREBP1c, FASN, ACACA & ↘TG | [66] |
lnc-KDM5D-4 | – | LINCxxxxa | h | KD (lnc) | HepG2 | ↗LPIN2 & ↗Lipid droplet formation | [67] |
lnc-leptin | – | lnc-leptina | m | KD (lnc) | Primary adipocyte | ↘LEP | [68] |
lncLSTR | C730036E19Rik (m: 1tr; 1102 bp; 5ex) | lncLSTR | m | KD (lnc) | Liver | ↗APOC2, ↘CYP8B1 & ↘TG, Glucose | [69] |
lncLTR | NONGGAG001747.2 (c: 1tr; 776 bp; NA) | lncLTRa | c | GWAS (serum TG content) | – | SNP in lncLTR locus | [70] |
lncSHGL | B4GALT1-AS1 d (h: 3tr; 3752 bp; 4ex) | lncSHGLa | m | KD, Ov. (lnc) | Liver | ↗ACACB, ↘FASN, SREBP1 & ↘FA, lipolyse | [71] |
lncSREBF1 | SMCR2 (h:1tr; 564 bp; 4ex) | SMCR2a | h | Co-effects (LXR agonist) | THP-1 | ↗lnc | [62] |
LNMICC | AC009902.2 (h: 2tr; 620 bp; 2ex) | LNMICCa | h | KD, Ov. (lnc) | HeLa229 | ↗ACACA, FASN, FABP5, ↘ACOX1, CPT1A & ↗TG, PL | [72] |
LOC100506036 | CNNM3-DT (h: 1tr; 415 bp; 2ex) | CNNM3-DT | h | KD (lnc) | Jurkat cells | ↘SMPD1, NFAT1 | [73] |
LOC157273 | AC022784.6 (h: 1tr; 559 bp; 1ex) | LINCxxxxa | h | GWAS (lipid-traits) | – | ↗lnc / SNP in the lncRNA locus | [74] |
MALAT1 | MALAT1 (h: 17tr; 1519 bp; 2ex) | MALAT1 | h | KD (lnc) | HepG2 | ↗SREBP1c & ↗TG, Chol. | [75] |
MEG3 | MEG3 (h: 50tr; 4867 bp; 2ex) | MEG3 | h,m | Ov. (lnc) | Liver HEK-293 T | ↗CYP7A1, CYP8B1, FXR, SREBP1c, ↘SHP | [76] |
m | KD (lnc) | Liver | ↘TG | [77] | |||
m | Co-effects (NAFLD) | Liver | ↗lnc, NRF2, ↘miR-136 & ↘serum lipid | [78] | |||
MeXis | AI427809 (m: 4tr; 2033 bp; 2ex) | MeXis | m | KO, Ov. (lnc) | Liver, Macrophage | ↗ABCA1 & ↗Chol. efflux | [37] |
NEAT1 | NEAT1 (h: 9tr; 3341 bp; 2ex) | NEAT1 | h | KD (lnc) | THP-1 | ↘TNFa, ↗CD36, OLR1 & ↗lipid uptake | [79] |
h | KD (lnc) | HCC | ↘ATGL, PPARa, ↗miR-124-3p | [80] | |||
OLMALINC | OLMALINC (h: 36tr; 5893 bp; 5ex) | OLMALINCa | h | Co-effects (obesity) | Adipose | ↘lnc, ↗lipid metabolism genes | [81] |
h | KD (lnc) | HepG2 | ↗SREBP2-dependent gene, ↘SREBP1 pathway genes | [82] | |||
PLA2G1Bat1 | ENSGALG00000041755 (c: 3tr; 2101 bp; 3ex) | LINCxxxxa | c | Co-effects (Se-deficient diet) | Vein | ↘lnc, ↗PLA2G1B | [47] |
PVT1 | PVT1 (h:182tr; 1699 bp; 8ex) | PVT1a | h | KD (lnc) | U2OS MG-63 | ↗miR-195, ↘FASN | [83] |
RNCR3 | Mir124a-hg (m: 4tr; 4103 bp; 4ex) | RNCR3a | m | KD (lnc) | Plasma | ↗TG, Chol. | [84] |
RP1-13D10.2 | AL021407.3 (h: 1tr; 486 bp; 1ex) | LINCxxxxa | h | Ov. (lnc) | Huh7, HepG2 | ↗LDLR & ↗LDL, ↘ApoB | [85] |
RP5-833A20.1 | NFIA-AS1 (h: 7tr; 384 bp; 4ex) | NFIA-AS1 | h | KD, Ov. (lnc) | THP-1 | ↗miR-382, ↘NFIA & ↗Chol. | [86] |
SNHG14 | Snhg14 (m: 15tr; 6861 bp;1 2ex) | SNHG14 | m | KD, Ov. (lnc) | BV-2 | ↘PLA2G4A | [87] |
SNHG16 | SNHG16 (h: 13tr; 3607 bp; 3ex) | SNHG16a | h | KD (lnc) | HCT119 | ↘SCD, PCSK9, SQLE, ACLY, INPP5D, HSD17B7 | [88] |
SPRY4-IT1 | SPRY4-AS1 (h: 7tr; 1293 bp; 5ex) | SPRY4-IT1a | h | KD (lnc) | HEM-1 | ↘DGAT2, GPAT3 & ↘Acyl Carnitine, FA, TG | [89] |
SRA | Sra1b (m: 2tr; 1299 bp; 4ex) | SRA1 | m | KO (lnc) | Liver | ↗ATGL | [90] |
m | KO (lnc) | Liver | ↘PPARA, PPARG, FABP4, SCD & ↘TG, FA | [91] | |||
TRIBAL | AC091114.1 (h: 2tr; 1272 bp; 3ex) | TRIBAL | h | GWAS (TG) | – | SNP in TRIBAL locus | [92] |
uc.372 | – | RALGAPA1-AS1a | h,m | Ov. (lnc) | Liver, HepG2 | ↗ACACA, FASN, SCD, CD36 & ↗TG, Chol. | [93] |
XLOC_011279 | – | LINCxxxxa | p | Co-effects (fat line) | Adipose | ↗lnc, LPIN1 | [94] |
XLOC_013639 | – | LINCxxxxa | p | Co-effects (fat line) | Adipose | ↗lnc, SCD | [94] |
XLOC_014379 | – | NF1-IT1a | p | Co-effects (fat line) | Adipose | ↗lnc, SCD | [94] |
XLOC_019518 | – | RNF7-DTa | p | Co-effects (fat line) | Adipose | ↗lnc, SCD | [94] |
XLOC_064871 | – | LINCxxxxa | p | Co-effects (fat line) | Adipose | ↗lnc, TRIB3 | [94] |