Table 2 Mechanisms of action reported for 25 lncRNAs

APOA1-AS

h

Histone mark modification via LSD1 et SUZ12 (PRC2)

[41]

APOA4-AS

m

Complex lnc:HuR et APOA4 mRNA

[42]

Blnc1^a

m

Complex lnc:hnRNPU / Complex lnc:EDF1, lnc:LXRa

[95]

CASIMO1^a

h

Small protein CASIMO1 interacts with SQLE protein

[45]

H19

m

Complex lnc:PTBP1 which targets SREBP1c mRNA and protein stability and transcriptional activity

[50]

LeXis

m

Complex lnc:RALY (hnRNP) which targets SREBP2, HMGCR, CYP51A1, FDPS promoters

[55]

LINC01138

h

Comple lnc:PRMT5 which targets SREBP1 in order to regulate its arginine methylation and to stabilize SREBP1 mRNA

[56]

linc-ADAL^a

h

Complex lnc:IGF2BP2 and hnRNPU

[57]

LINK-A^a

h

Complex lnc:PIP3 increases interaction with Akt

[59]

lnc-HC

r

Complex lnc:hnRNPA2B1 which targets CYP7A1/ABCA1 mRNAs

[65]

Lnc-leptin^a

m

Loop between LEP and its enhancer (near lnc:leptin locus)

[68]

lncLGR^a

m

Complex lnc:hnRNPL which targets GCK promoter

[96]

lncLSTR

m

Complex lnc:TDP-43 which targets CYP8B1 promoter

[69]

lncSHGL^a

m

Complex lnc:hnRNPA1 which targets CALM mRNA to increase its translation

[71]

LNMICC^a

h

Complex lnc:NPM1 which targets FABP5 promoter

[72]

MALAT1

h

Complex lnc:SREBP1c which stabilizes nuclear SREBP1c protein

[75]

MEG3

h,m

Complex lnc:PTBP1 which targets SHP mRNA for its decay

[76]

MeXis

m

Complex lnc:DDX17 which targets ABCA1 promoter

[37]

NEAT1

h

Complex lnc:NONO:CD36 mRNA

[79]

h

ceRNA (miR-124-3p which targets ATGL)

[80]

PVT1^a

h

ceRNA (miR-195 which targets FASN)

[83]

RALGAPA1-AS1^a

h,m

Stop maturation of pri-miRNA (pri-miR-195/pri-miR-4668)

[93]

S1PR1-DT^a

h

Complex lnc:ZNF354C which inhibits its repressive activity

[60]

SNHG14

m

ceRNA (miR-145-5p which targets PLA2G4A)

[87]

SNHG16^a

h

ceRNA (multiple miRNA which target SCD) & Complex lnc:HuR

[88]

SPRY4-IT1^a

h

Complex lnc:Lipin2

[89]