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Table 5 Sex-related genes previously described in Actinopterygii that matched with GWAS candidate regions identified in this study

From: Identification of genomic regions regulating sex determination in Atlantic salmon using high density SNP data

Genes Location Functional group Functional role in sex Reference
SDY Ssa02, 19, 20 Interferon regulatory factor Up-regulation of inhibitors of CYP19A (cytochrome P450 aromatase), preventing the accumulation of estrogens required for female development. [8, 9, 16]
SOX family Ssa01–3, 5–7, 9–10, 12–17, 19, 21–23, 25–29 Transcription factors Testis development and male fertility in mammals. Sertoli cell differentiation and seminiferous tubule formation. [31, 32]
RSPO1 Ssa02, 5 Activator protein Activator of ovarian determination and differentiation through the WNT/β-catenin signaling pathway. [33, 34]
LMO7 Ssa21, 25 Protein-protein interactions Regulation of transcription of the emerin gene, an inhibitor of the WNT/β-catenin signaling pathway through beta-catenin. [35, 36]
ESR1 Ssa02, 6, 15 Ligand-activated transcription factor Estrogen nuclear receptor involved in female development in vertebrates. Maintenance of development and maintenance of female status. [37, 38]
U2AF2A Ssa02, 14, 15, 27 Binding factor Steroid receptor. Regulation of transcription mediated by steroid hormone receptors and alternative sex-specific splicing in vertebrates. Female sex differentiation. [39]
GNRH-R Ssa02, 5, 23 Binding factor Receptor of gonadotropin-releasing hormone. Regulation of female reproduction in vertebrates. [40, 41]
DND Ssa17, 21 Binding factor Germ-cell-marker gene in many vertebrates. Involved in primordial germ cell migration and survival in teleosts. [42]
FIGLA Ssa02, 20, 21 Transcription factor Germ-cell-specific transcription factor associated with ovary development and differentiation in vertebrates. [43]
  1. For each gene, the chromosomal location in Atlantic salmon candidate regions identified in this study, the functional group to which the gene belongs to, its functional role in sex and corresponding references, are provided