Fig. 1

Comparisons of characteristics of mi-eQTL in brain with statistical significance. Log transformed LOD scores are for visualization reasons only. The actual calculations were done on untransformed LOD scores. a The difference in mi-eQTL strength between cis and trans mi-eQTL (Wilcoxon summed rank test-statistic (W) = 183, p-value = 0.023). b The difference in mi-eQTL strength between mi-eQTL of annotated miRNA compared to mi-eQTL of novel miRNA (W = 59, p-value = 0.028). c The difference in mi-eQTL strength between mi-eQTL with miRNA in intronic locations compared to those in non-intronic locations (W = 229, p-value = 0.067). d The difference in strength between mi-eQTL involving miRNAs that were highly conserved (mean PhastCon conservation score above 0.5) compared to those involving lowly conserved miRNAs (W = 108, p-value = 0.169). The conservation scores were dichotomized at 0.5 because that were often close to zero or one. e The relationship between mi-eQTL strength and the heritability (measured by the intraclass correlation coefficient) of the miRNA involved (in the mi-eQTL) (rho = 0.82, p-value = 3.67e-8)