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Table 3 Brain-related enriched pathways obtained for annotated miRNA with a significant mi-eQTL

From: Insight into genetic regulation of miRNA in mouse brain

miRNA

Brain Related KEGG Pathway

# of genes

FDR

miR-547-3p

Axon guidance

5

0.0165

mmu-miR-32-3p

GABAergic synapse

7

< 0.0001

 

Glutamatergic synapse

8

0.0007

 

Nicotine addiction

5

0.0045

 

Morphine addiction

6

0.0046

 

Amphetamine addiction

7

0.0052

 

Axon guidance

9

0.0095

mmu-miR-208b-3p

Glioma

5

0.0007

 

Neurotrophin signaling pathway

6

0.0346

mmu-miR-8114

Axon guidance

5

0.0456

mmu-miR-677-5p

mTOR signaling pathway

13

0.0037

 

Cocaine addiction

8

0.0273

mmu-miR-6929-3p

Ubiquitin mediated proteolysis

5

0.0208

mmu-miR-465c-5p

GABAergic synapse

9

< 0.0001

 

Morphine addiction

10

< 0.0001

 

Nicotine addiction

6

0.0028

mmu-miR-193a-3p

Glioma

4

0.0015

mmu-miR-466q

Nicotine addiction

4

0.0038

mmu-miR-7674-5p

Axon guidance

5

0.0010

  1. FDR are the adjusted p-values. Only pathways with 4 or more genes and an FDR less than 5% are shown in the table. Pathways were deemed brain related if the PubMed search of the pathway name AND the keyword “brain” yielded at least one abstract. The abstract(s) were read to confirm brain related research