Fig. 7

Cross-validated representative profiles of genes that were responsive to LPS stimulation. Genes showing differential expression (|log₂(fold change)| ≥ log₂(1.2) and q < 0.05) post LPS injection compared to baseline were cross-validated by using independent time-series gene expression microarray data on response of pigs’ whole blood to LPS [23]. The y-axis shows the log₂ fold change of gene expression at each time point relative to baseline, estimated by DESeq2 or limma. Smoothed expression profiles of individual genes per line were inferred by using LOWESS (Locally Weighted Scatterplot Smoothing). HRFI, high-RFI line; LRFI, low-RFI line; Normal, pigs not selected for RFI [23]