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Table 8 The top 25 human candidate aging genes

From: Genome-wide prediction and prioritization of human aging genes by data fusion: a machine learning approach

RankGene symbolRelevanceReferenceDatabase reference
1NAP1L4Nucleosome Assembly[32, 33] 
2CCNI
(CYC1)
Parkinson Disease[34]BEFREE
3RPL3Ribosomal Protein[35] 
4FZD5Alzheimer’s Disease[36]BEFREE
5BRD2Diabetes Mellitus, Non-Insulin-Dependent
Osteoporosis, Postmenopausal
Colorectal Cancer
[37,38,39,40]BEFREE
6ATP8A2ATPase Phospholipid Transporting[41] 
7SRSF11Serine And Arginine Rich Splicing Factor[42] 
8BBIP1   
9IL10Cardiovascular Diseases
Diabetes Mellitus, Non-Insulin-Dependent
Colorectal Cancer
Atherosclerosis
Parkinson Disease
Alzheimer’s Disease
Arthritis
Heart failure
[43, 44]
[45,46,47]
[48, 49]
[50, 51]
[52,53,54]
[55,56,57]
[58,59,60]
[61,62,63]
CTD_human
RGD
LHGDN
BEFREE
HPO
10FYCO1Cataract, autosomal recessive congenital 2
Cataract
[64, 65]UNIPROT
GENOMICS_ENGLAND
HPO
CTD_human
11PSMB2   
12NSFParkinson Disease[66,67,68,69,70]GWASDB
GWASCAT
BEFREE
13OAZ1   
14ZFP36L1   
15PCLODiabetes Mellitus, Non-Insulin-Dependent[71]BEFREE
16GAB2Alzheimer’s Disease
Colorectal Cancer
Osteopetrosis
[72,73,74,75]
[76, 77]
[78]
BEFREE
GWASDB
GWASCAT
17QKICoronary heart disease
Colorectal Cancer
[79]BEFREE
UNIPROT
18ZNF638   
19RGS3   
20XPO6   
21ATP8B1Colorectal Cancer[80]BEFREE
22ITM2C   
23RBFOX1Heart failure
Colorectal Cancer
[81]
[82]
BEFREE
24DLC1Colorectal Cancer
Hereditary Diffuse Gastric Cancer
Coronary heart disease
Increased gastric cancer
[83]
[84]
[85]
BEFREE
CTD_human
HPO
25MVKArthritis
Cataract
 HPO
HPO