Table 8 The top 25 human candidate aging genes
| Rank | Gene symbol | Relevance | Reference | Database reference |
|---|---|---|---|---|
| 1 | NAP1L4 | Nucleosome Assembly | [32, 33] | |
| 2 | CCNI (CYC1) | Parkinson Disease | [34] | BEFREE |
| 3 | RPL3 | Ribosomal Protein | [35] | |
| 4 | FZD5 | Alzheimer’s Disease | [36] | BEFREE |
| 5 | BRD2 | Diabetes Mellitus, Non-Insulin-Dependent Osteoporosis, Postmenopausal Colorectal Cancer | [37,38,39,40] | BEFREE |
| 6 | ATP8A2 | ATPase Phospholipid Transporting | [41] | |
| 7 | SRSF11 | Serine And Arginine Rich Splicing Factor | [42] | |
| 8 | BBIP1 | |||
| 9 | IL10 | Cardiovascular Diseases Diabetes Mellitus, Non-Insulin-Dependent Colorectal Cancer Atherosclerosis Parkinson Disease Alzheimer’s Disease Arthritis Heart failure | [43, 44] [45,46,47] [48, 49] [50, 51] [52,53,54] [55,56,57] [58,59,60] [61,62,63] | CTD_human RGD LHGDN BEFREE HPO |
| 10 | FYCO1 | Cataract, autosomal recessive congenital 2 Cataract | [64, 65] | UNIPROT GENOMICS_ENGLAND HPO CTD_human |
| 11 | PSMB2 | |||
| 12 | NSF | Parkinson Disease | [66,67,68,69,70] | GWASDB GWASCAT BEFREE |
| 13 | OAZ1 | |||
| 14 | ZFP36L1 | |||
| 15 | PCLO | Diabetes Mellitus, Non-Insulin-Dependent | [71] | BEFREE |
| 16 | GAB2 | Alzheimer’s Disease Colorectal Cancer Osteopetrosis | [72,73,74,75] [76, 77] [78] | BEFREE GWASDB GWASCAT |
| 17 | QKI | Coronary heart disease Colorectal Cancer | [79] | BEFREE UNIPROT |
| 18 | ZNF638 | |||
| 19 | RGS3 | |||
| 20 | XPO6 | |||
| 21 | ATP8B1 | Colorectal Cancer | [80] | BEFREE |
| 22 | ITM2C | |||
| 23 | RBFOX1 | Heart failure Colorectal Cancer | [81] [82] | BEFREE |
| 24 | DLC1 | Colorectal Cancer Hereditary Diffuse Gastric Cancer Coronary heart disease Increased gastric cancer | [83] [84] [85] | BEFREE CTD_human HPO |
| 25 | MVK | Arthritis Cataract | HPO HPO |
