Table 8 The top 25 human candidate aging genes

1

NAP1L4

Nucleosome Assembly

[32, 33]

2

CCNI

(CYC1)

Parkinson Disease

[34]

BEFREE

3

RPL3

Ribosomal Protein

[35]

4

FZD5

Alzheimer’s Disease

[36]

BEFREE

5

BRD2

Diabetes Mellitus, Non-Insulin-Dependent

Osteoporosis, Postmenopausal

Colorectal Cancer

[37,38,39,40]

BEFREE

6

ATP8A2

ATPase Phospholipid Transporting

[41]

7

SRSF11

Serine And Arginine Rich Splicing Factor

[42]

8

BBIP1

9

IL10

Cardiovascular Diseases

Diabetes Mellitus, Non-Insulin-Dependent

Colorectal Cancer

Atherosclerosis

Parkinson Disease

Alzheimer’s Disease

Arthritis

Heart failure

[43, 44]

[45,46,47]

[48, 49]

[50, 51]

[52,53,54]

[55,56,57]

[58,59,60]

[61,62,63]

CTD_human

RGD

LHGDN

BEFREE

HPO

10

FYCO1

Cataract, autosomal recessive congenital 2

Cataract

[64, 65]

UNIPROT

GENOMICS_ENGLAND

HPO

CTD_human

11

PSMB2

12

NSF

Parkinson Disease

[66,67,68,69,70]

GWASDB

GWASCAT

BEFREE

13

OAZ1

14

ZFP36L1

15

PCLO

Diabetes Mellitus, Non-Insulin-Dependent

[71]

BEFREE

16

GAB2

Alzheimer’s Disease

Colorectal Cancer

Osteopetrosis

[72,73,74,75]

[76, 77]

[78]

BEFREE

GWASDB

GWASCAT

17

QKI

Coronary heart disease

Colorectal Cancer

[79]

BEFREE

UNIPROT

18

ZNF638

19

RGS3

20

XPO6

21

ATP8B1

Colorectal Cancer

[80]

BEFREE

22

ITM2C

23

RBFOX1

Heart failure

Colorectal Cancer

[81]

[82]

BEFREE

24

DLC1

Colorectal Cancer

Hereditary Diffuse Gastric Cancer

Coronary heart disease

Increased gastric cancer

[83]

[84]

[85]

BEFREE

CTD_human

HPO

25

MVK

Arthritis

Cataract

HPO

HPO