Fig. 2

Pathway behavior by time with part of Thy-Thy Synchronization data. KEGG Cell Cycle pathway is drawn by Rgraphviz package[30]. The activated pathway routes are highlighted in red. The cell cycle phase is notated by [24]. The notation in [24] is fuzzy thus the phase on transition time point between different phases may not be completely accurate. Periodical pathway activation behavior can be observed. From the visualization, we can also see that the pathway routes has an up and down behavior pattern. And the same phase time point share similar pathway behavior as the same section of pathway gets highlighted. The biological markers for each phase are drawn as rectangles instead of circles