Fig. 4

(a) The heatmap for Cell Cycle pathway route scores: the columns corresponds to time points and the rows corresponds to pathway routes. Red indicates enhancement while blue indicates suppressiveness. Periodically up and down behavior can be observed as the time flows. Certain route scores behaves distinctly during different phases. (b) Receiver operating characteristic (ROC) curve for p53 mutation pathway prediction. The orange, red, blue, green and purple curve corresponds to t=0.1,0.3,0.5,0.7,0.9 in (3) respectively. The threshold is picked from [0,1] with a step of 1/10000. (c) Proportion of pathways correctly predicted for each pathway analysis tools. (d) False positive vs True positive −log(SigScore) box plot