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Table 1 Predicted gene targets for differentially expressed microRNAs (> 2 log2 fold, P < 0.0001) that correlate with S. carpocapsae strain behaviour. Differentially expressed S. carpocapsae microRNAs were assessed for binding sites across 5′ and 3’UTRs of all ion channel, innexin, GPCR, neurotransmitter and neuropeptide genes. Ce target refers to direct 1 to 1 gene orthologues that are biochemically confirmed microRNA targets in C. elegans [20]. U refers to the number of predicted interacting microRNAs following default microRNA target prediction; S refers to the number of predicted interacting microRNAs following strict microRNA target prediction. Within the implicated behaviour column, “Both (inverse int.)” refers to involvement in both behaviours, through polarised regulation states (significantly upregulated for one, and significantly downregulated for the other)

From: Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles

 microRNAGeneGene NameGene familyCe targetDSImplicated behaviour
3’UTRsc-miR-301-3pL596_g12890.t2twk-12Ion Channely21Chemotaxis
sc-miR-301-3pL596_g12890.t3twk-12Ion ChannelY21Chemotaxis
sc-miR-301-3pL596_g12890.t1twk-12Ion Channely21Chemotaxis
sc-miR-759L596_g2695.t1acr-21Ion Channel 21Nictation
sc-miR-138L596_g3511.t1eat-5Innexin 20Chemotaxis
sc-miR-117L596_g24535.t1ador-1GPCR 20Chemotaxis
sc-miR-283L596_g24535.t1ador-1GPCR 20Chemotaxis
sc-miR-84-5piL596_g1430.t1ins-1bNeuropeptidey21Nictation
5’UTRsc-miR-147L596_g23064.t1asic-2iiIon Channel 22Chemotaxis
sc-miR-147L596_g14933.t1unc-36Ion Channel 22Chemotaxis
sc-miR-156L596_g11170.t1egas-1Ion Channel 22Chemotaxis
sc-miR-176L596_g11280.t1lgc-22Ion Channel 22Chemotaxis
sc-miR-184L596_g11170.t1egas-1Ion Channel 30Chemotaxis
sc-miR-184L596_g13756.t1acr-25Ion Channel 22Chemotaxis
sc-miR-190L596_g21438.t2unc-2Ion Channely33Chemotaxis
sc-miR-190L596_g21438.t1unc-2Ion Channely33Chemotaxis
sc-miR-190L596_g25880.t2slo-1Ion Channely22Chemotaxis
sc-miR-190L596_g25880.t1slo-1Ion Channely22Chemotaxis
sc-miR-211L596_g19116.t1unc-49Ion Channely55Chemotaxis
sc-miR-299L596_g11170.t1egas-1Ion Channel 21Chemotaxis
sc-miR-301-3pL596_g11170.t1egas-1Ion Channel 31Chemotaxis
sc-miR-301-3pL596_g23064.t1asic-2iiIon Channel 21Chemotaxis
sc-miR-301-5piL596_g9175.t1clhm-1Ion Channel 22Chemotaxis
sc-miR-301-5piL596_g13756.t1acr-25Ion Channel 21Chemotaxis
sc-miR-301-5piiL596_g13756.t1acr-25Ion Channel 21Chemotaxis
sc-miR-301-5piiL596_g11170.t1egas-1Ion Channel 22Chemotaxis
sc-miR-301-5piiL596_g9175.t1clhm-1Ion Channel 20Chemotaxis
sc-miR-306L596_g21215.t1twk-46Ion Channel 21Chemotaxis
sc-miR-316L596_g14933.t1unc-36Ion Channel 22Chemotaxis
sc-miR-316L596_g23064.t1asic-2iiIon Channel 22Chemotaxis
sc-miR-337L596_g9175.t1clhm-1Ion Channel 20Chemotaxis
sc-miR-338L596_g14875.t1kvs-5Ion Channel 21Chemotaxis
sc-miR-351L596_g15440.t1twk-43Ion Channel 21Chemotaxis
sc-miR-756L596_g9186.t2twk-2Ion Channel 22Nictation
sc-miR-756L596_g9186.t1twk-2Ion Channel 22Nictation
sc-miR-759L596_g15570.t1shk-1Ion Channely21Nictation
sc-miR-772L596_g15357.t1clh-5Ion Channel 21Nictation
sc-miR-772L596_g15357.t2clh-5Ion Channel 21Nictation
sc-miR-772L596_g11576.t1avr-14Ion Channely20Nictation
sc-miR-775L596_g20944.t1twk-29Ion Channel 22Chemotaxis
sc-miR-91L596_g12530.t1unc-58Ion Channel 21Nictation
sc-miR-759L596_g25584.t1unc-7InnexinY22Nictation
sc-miR-138L596_g9922.t1gar-2GPCRy20Chemotaxis
sc-miR-151L596_g14843.t1npr-26GPCR 22Both (inverse int.)
sc-miR-184L596_g17321.t1npr-23GPCRy20Chemotaxis
sc-miR-27L596_g22293.t1C30A5.10GPCR 21Both (inverse int.)
sc-miR-301-5piL596_g14261.t2npr-11GPCR 21Chemotaxis
sc-miR-351L596_g16439.t1srsx-24GPCR 22Chemotaxis
sc-miR-756L596_g17321.t1npr-23GPCRy21Nictation
sc-miR-761L596_g25676.t1gar-1GPCR 21Nictation
sc-miR-773L596_g25676.t1gar-1GPCR 20Nictation
Sc-let-7L596_g13647.t1ins-1aNeuropeptidey21Nictation
sc-miR-301-3pL596_g14298.t1nlp-49Neuropeptide 21Chemotaxis
sc-miR-84-5piL596_g5500.t2vglu-2Neurotransmission 22Both (inverse int.)