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Table 1 Top loci associated with conception rate to first breeding and number of breedings to conception

From: Identification of loci associated with conception rate in primiparous Holstein cows

BTA1

BP Position2

SNP ID3

Model4

CCR1

P-value5

TBRD

P-value6

Positional Candidate Gene(s)7

TFBS8

3

111,540,905

(110,948,044)

rs133945887

Recessive

1.33 × 10−14

7.25 × 10−12

GJB5, GJB4

–

6

38,447,022

(37,013,919)

rs109381958

Additive

Dominant

4.31 × 10−30

4.31 × 10− 30

4.39 × 10− 26

4.39 × 10− 26

–

–

6

93,660,111

(91,908,296)

rs132854961

Recessive

1.56 × 10− 14

8.38 × 10− 12

CCNI, LOC101901983

–

8

29,615,889

(29,565,411)

rs134405734

Additive

Dominant

1.42 × 10− 36

1.42 × 10− 36

1.25 × 10− 24

1.25 × 10− 24

ZDHHC21

–

16

387,363

(591,660)

rs133778157

Additive

Dominant

2.99 × 10− 33

2.99 × 10− 33

5.68 × 10− 28

5.68 × 10− 28

LOC787642, LOC787620, LOC787667

–

16

10,340,087

(9,739,230)

rs137501137

Recessive

5.27 × 10− 14

1.12 × 10− 13

–

NF-1, Cutl1

17

74,944,074

(72,930,491)

rs133921184

Additive

Dominant

3.35 × 10−37

2.93 × 10− 37

2.59 × 10− 23

5.98 × 10− 22

ARVCF, COMT

–

20

23,886,196

(23,863,171)

rs41663374

Recessive

9.41 × 10− 17

1.58 × 10− 11

DHX29, LOC107131567

–

  1. 1Chromosome location of the locus
  2. 2Single nucleotide polymorphism (SNP) location as measured by numbered nucleotides in reference to the UMD 3.1 genome assembly (http://bovinegenome.org/?q=node/61; accessed 15 September 2016) or the ARS 1.2 genome assembly (https://www.animalgenome.org/repository/cattle/UMC_bovine_coordinates/; accessed 19 September 2018) in parentheses
  3. 3The most significant SNP in the locus associated cow conception rate as identified by rs number which is a reference number assigned to markers submitted to the National Center for Biotechnology Information SNP database (https://www.ncbi.nlm.nih.gov/projects/SNP/; accessed 2 April 2018)
  4. 4Genome-wide association model
  5. 5Significance (P-value) of the most significant SNP associated with cow conception rate at first service (CCR1)
  6. 6Significance (P-value) of the most significant SNP associated with number of services per conception (TBRD)
  7. 7Positional candidate genes are defined as genes that are located within 17.8 kb on either side of the associated SNP(s)
  8. 8Transcription factor binding sites (TFBS) as identified using the Alggen Promo database (http://alggen.lsi.upc.es/cgi-bin/promo_v3/promo/promoinit.cgi?dirDB=TF_8.3; accessed 26 July 2018)