Table 2 Genes and corresponding conserved domains linked to integrative, conjugative and resistance elements found in contigs 5, 7 and 9 from the draft assembly of strain GP. Families and E-values in bold indicate the best hits obtained with CONJscan [146]. n.a., not applicable

 Replication, stabilization and partitioning

D3X82_17420

Toxin protein from a toxin/antitoxin system

Zeta_toxin

pfam06414

1.6e-19

D3X82_17550

Plasmid partition protein A

BcsQ

partition_RepA

COG1192

TIGR03453

2.2e-43

5.7e-16

D3X82_17555

Single-stranded DNA-binding protein

SSB_OBF

cd04496

8.5e-12

D3X82_18090

Plasmid replication protein

RepA_C

pfam04796

9.0e-07

 Mobilization and conjugative elements

D3X82_17410

Plasmid mobilization relaxosome protein MobC

MobC

pfam05713

5.7e-05

D3X82_17470

Conjugal transfer protein

TrwC

MOB_F

pfam08751

n.a.

9.0e-97

1.3e-85

D3X82_17385

Type IV secretion protein (T4SS)

VirB4

n.a.

1.40e-25

D3X82_17390

Coupling protein (T4CP)

VirD4

T4CP2

COG3505

n.a.

4.2e-16

5.7e-40

D3X82_17405

Relaxase

Relaxase

MOB_P1

pfam03432

n.a.

9.8e-10

4.20e-40

D3X82_18105

Conjugal transfer protein

TrwC

MOB_F

pfam08751

n.a.

3.7e-28

5.3e-105

D3X82_18250

Conjugal transfer protein

TrwC

MOB_F

pfam08751

n.a.

7.6e-25

4.1e-106

 Multi-drug and heavy metal resistance

D3X82_17365 D3X82_17695

Sulfonamide monooxygenase SadA

NcnH

CaiA

Acyl-CoA_dh_2

cd01159

COG1960

pfam08028

1.52e-84

1.93e-30

5.8e-20

D3X82_17485

Tet(A)/Tet(B)/Tet(C) family tetracycline efflux MFS transporter

MFS_TetA

cd17388

2.4e-145

D3X82_17505

ANT(3″)-Ia family aminoglycoside nucleotidyltransferase AadA1

PRK13746

DUF4111

PRK13746

pfam13427

0e+ 00

1.31e-41

D3X82_17510

Quaternary ammonium compound efflux SMR transporter QacE delta 1

Multi_Drug_Res

pfam00893

1.75e-28

D3X82_17515

Sulfonamide-resistant dihydropteroate synthase Sul1

Pterin_bind

pfam00809

1.8e-87

D3X82_17685

Mercury(II) reductase

MerA

TIGR02053

1.2e-171