Fig. 3
From: Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA
APOBEC1 cytidine deaminase activity on plasmid and cytosolic mitochondrial DNA. a Graphical representation of plasmid DNA editing by A1 proteins. The temperature of the DNA products recovered at the lowest Td by kanamycin specific 3DPCR amplification are represented on the gradient. b Dinucleotide analysis of the deamination context performed on plasmid DNA for PCR products retrieved at 84.6 °C. c Graphical representation of cytochrome c mtDNA editing by A1 proteins. The last retrieved bands by cytochrome c specific 3DPCR amplification are represented on the gradient. d Dinucleotide analysis of the deamination context performed on mtDNA for PCR products retrieved at 82.3 °C. Dinucleotide context expected values, based on the dinucleotide composition of DNA sequences are represented by white histograms. * Significant deviation from expected values (χ2-test, P < 0.05)