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Fig. 4 | BMC Genomics

Fig. 4

From: Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice

Fig. 4

General upregulation of Collagens and Laminins due to young running with an attenuated response at midlife. a Number of significant collagen, laminin or other genes in young ‘Hepatic Fibrosis’ and ‘GP6 Signaling’ pathways in the cortex and hippocampus. b Fold changes of genes enriching for ‘GP6 Signaling’ in the cortex. c Fold changes of genes enriching for ‘GP6 Signaling’ in the hippocampus. d Heatmap of Col4s and laminins in the cortex and hippocampus that are significant in young run compared to young sedentary, while not significant in midlife comparisons. e Examples of significant cortical genes found in (d) showing attenuated responses in midlife cohort contrasts compared to young. f Examples of significant hippocampal genes found in (d) showing various responses in midlife cohort contrasts compared to young

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