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Fig. 7 | BMC Genomics

Fig. 7

From: Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice

Fig. 7

Running young is more effective than running at midlife. a Depiction of transcriptional changes occurring in a young mouse due to running, including upregulation of collagens and laminins from astrocytes, pericytes and endothelial cells, as well as induction of the VEGFA-KDR-DLL4 angiogenesis pathway. b Depiction of molecular changes occurring in midlife mice due to running, including downregulation of collagens and laminins, and a trend for induction of early angiogenesis genes from astrocytes (MMP14, VEGFA) but an attenuated downstream angiogenesis response (FLT-1, DLL4, NOTCH1) in endothelial cells

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BMC Genomics

ISSN: 1471-2164

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